Β-lactam resistance: Difference between revisions
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Β-lactam resistance
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Revision as of 00:11, 15 August 2019
Beta-lactam resistance
Mechanisms
- ß-lactamase production: enzymatic breakdown of beta lactam antibiotic
- Penicillin binding protein mutations (e.g. MRSA)
- Efflux pump mutations
- Porin channel mutations that reduce antibiotic influx
Ambler Classification of ß-lactamases
- Based on amino acid sequences rather than function
- Classes A, C, and D are serine ß-lactamases
- Class A: original active-site serine ß-lactamases
- Class B: original metallo-ß-lactamases
- Class C: AmpC ß-lactamases
- Class D: OXA ß-lactamases
