Rheumatic heart disease: Difference between revisions
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==Background== |
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*Delayed autoimmune reaction to group A [[streptococcal pharyngitis]] |
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===Pathophysiology=== |
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== Epidemiology == |
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=== Epidemiology === |
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== Clinical Manifestations == |
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* Almost always affects the mitral valve with isolate mitral stenosis being the most common |
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* Mitral regurgitation, aortic stenosis, and aortic regurgitation also possible |
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* Acute rheumatic fever can cause inflammation of essentially any part of the heart |
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==Investigations== |
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==Complications== |
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==Management== |
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* Prophylaxis |
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*Prophylaxis, including patients with mild latent disease on echo |
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[[Category:Cardiology]] |
[[Category:Cardiology]] |
Latest revision as of 01:19, 22 December 2021
Background
- Delayed autoimmune reaction to group A streptococcal pharyngitis
Pathophysiology
- Cross-reactivity of anti-streptococcal antibodies with interstitial cardiac valvular cells
Epidemiology
- Occurs in about 3% of cases of untreated streptococcal pharyngitis
Clinical Manifestations
- Almost always affects the mitral valve with isolate mitral stenosis being the most common
- Mitral regurgitation, aortic stenosis, and aortic regurgitation also possible
- Acute rheumatic fever can cause inflammation of essentially any part of the heart
Investigations
- Anti-streptolysin-O titre (ASOT)
- >116 is suggestive of recent group A streptococcal infection
Complications
- Carditis leading to rheumatic heart disease in 30-45% of cases
Management
- Acute
- Antibiotics
- First-line: penicillin V for 10 days
- Alternative: amoxicillin for 10 days
- If carditis, add antiinflammatory
- First-line: high-dose ASA 20mg/kg?? (~1.3g) po qid
- Alternative: prednisone 1g/kg po daily with a 9-week taper
- Antibiotics
- Prophylaxis, including patients with mild latent disease on echo
- Benzathine penicillin G 1.2mU IM q3-4week