Γ-glutamyltransferase: Difference between revisions
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Γ-glutamyltransferase
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[[Category:Investigations]] |
[[Category:Investigations]] |
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{{DEFAULTSORT:gamma-glutamyltransferase}} |
{{DEFAULTSORT:gamma-glutamyltransferase}} |
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== Background == |
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* Liver enzyme in microsomes that catalyzes transfer of γ-glutamyl group from peptides to other amino acids |
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== Interpretation == |
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* About 90% sensitive for [[cholestasis]] (with ALP) |
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**Often only rise after several days |
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* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]] |
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** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others |
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** Elevation is usually about twice the upper limit of normal |
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*Can also see isolated elevations in [[COPD]], [[AKI]] or [[CKD]], and [[acute myocardial infarction]][[CiteRef::giannini2005li]] |
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*May be elevated in [[NAFLD]] and [[hepatitis C]] and other liver or biliary diseases |
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Latest revision as of 13:58, 10 November 2021
Background
- Liver enzyme in microsomes that catalyzes transfer of γ-glutamyl group from peptides to other amino acids
Interpretation
- About 90% sensitive for cholestasis (with ALP)
- Often only rise after several days
- Isolated elevation of GGT may be caused by enzyme induction from alcohol or aromatic medications, without liver disease1
- Aromatic medications include, commonly, phenobarbital, phenytoin, and others
- Elevation is usually about twice the upper limit of normal
- Can also see isolated elevations in COPD, AKI or CKD, and acute myocardial infarction2
- May be elevated in NAFLD and hepatitis C and other liver or biliary diseases
References
- ^ PMID10221307
- ^ E. G. Giannini. Liver enzyme alteration: a guide for clinicians. Canadian Medical Association Journal. 2005;172(3):367-379. doi:10.1503/cmaj.1040752.
