Nocardia: Difference between revisions
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Nocardia
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*Beaded [[Stain::Gram-positive]] [[Stain::partially acid-fast]] [[Shape::bacillus]] |
*Beaded [[Stain::Gram-positive]] [[Stain::partially acid-fast]] [[Shape::bacillus]] |
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*Appearance similar to [[Actinomyces]], differentiated by acid fast staining ([[Actinomyces]] is ''not'' acid fast) |
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==Management== |
==Management== |
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Revision as of 16:06, 14 October 2021
Background
Microbiology
- Beaded Gram-positive partially acid-fast bacillus
- Appearance similar to Actinomyces, differentiated by acid fast staining (Actinomyces is not acid fast)
Management
- Mild to moderate: TMP-SMX
- Immunocompetent: 5-10 mg/kg split tid to qid
- Immunocompromised: 15 mg/kg split tid to qid
- Severe: TMP-SMX plus either amikacin or imipenem
- Other antimicrobials include ceftriaxone, minocycline, and linezolid
Duration
- Isolated cutaneous infection in immunocompetent host: 3 to 6 months
- Isolated cutaneous infection in immunocompromised host: 6 to 12 months
- Serious pulmonary infection: 6 to 12 months or longer
- Any non-cutaneous disease in immunocompromised host: at least 12 months, and possibly lifelong suppression
