Fever in a hospitalized patient: Difference between revisions
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**Inflammatory diseases |
**Inflammatory diseases |
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Revision as of 03:06, 15 March 2021
Background
Definition
- Core temperature >38.3ΒΊC
Pathophysiology
- Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds
- Either direct action or cytokine production that stimulates the organum vasculosum of the lamina terminalis (OVLT) in the hypothalamus
- Neurogenic fever
- Decoupling of oxidative phosphorylation, as in drug-induced fever
Differential Diagnosis
- Infectious
- Non-infectious
- Inflammatory diseases
- Drug-induced, including Γ-lactam antibiotics, sulphonamides, antipsychotics, propofol
- Traumatic brain injury or ischemic brain injury
- Endocrine fever
