Chronic myeloid leukemia: Difference between revisions
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==Clinical Manifestations== |
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*Triphasic: chronic phase, accelerated phase, and blast crisis |
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*Almost half are asymptomatic on diagnosis |
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*Presenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding |
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*Often have [[splenomegaly]], which can contribute to the abdominal fullness and cause LUQ or left shoulder pain |
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*Can present with anemia, very elevated WBCs, and elevated platelets |
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=== Prognosis and Complications === |
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* Outcomes are very good since the introduction of tyrosine kinase inhibitors |
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* Prognostic models exist, including Sokal, Euro (Hasford), EUTOS, and ELTS scores |
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== Differential Diagnosis == |
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* [[Leukemoid reaction]] |
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* [[Juvenile myelomonocytic leukemia]] |
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* [[Chronic myelomonocytic leukemia]] |
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* [[Chronic eosinophilic leukemia]] |
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* [[Chronic neutrophilic leukemia]] |
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== Diagnosis == |
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* Usually suspected in asymptomatic patient with typical findings in peripheral blood or bone marrow |
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* Confirmed with detection of BCR-ABL1 fusion gene in peripheral blood or bone marrow |
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== Management == |
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* Can use empiric [[hydroxyurea]] for cytoreduction while awaiting diagnosis if WBC >80 |
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[[Category:Hematology]] |
[[Category:Hematology]] |
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Revision as of 21:02, 26 February 2021
Clinical Manifestations
- Triphasic: chronic phase, accelerated phase, and blast crisis
- Almost half are asymptomatic on diagnosis
- Presenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
- Often have splenomegaly, which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
- Can present with anemia, very elevated WBCs, and elevated platelets
Prognosis and Complications
- Outcomes are very good since the introduction of tyrosine kinase inhibitors
- Prognostic models exist, including Sokal, Euro (Hasford), EUTOS, and ELTS scores
Differential Diagnosis
- Leukemoid reaction
- Juvenile myelomonocytic leukemia
- Chronic myelomonocytic leukemia
- Chronic eosinophilic leukemia
- Chronic neutrophilic leukemia
Diagnosis
- Usually suspected in asymptomatic patient with typical findings in peripheral blood or bone marrow
- Confirmed with detection of BCR-ABL1 fusion gene in peripheral blood or bone marrow
Management
- Can use empiric hydroxyurea for cytoreduction while awaiting diagnosis if WBC >80
