Escherichia coli: Difference between revisions

Latest revision as of 14:28, 8 October 2020

Background

Microbiology

Lactose-fermenting Gram-negative bacillus within the Enterobacteriaceae
Can also be non-lactose-fermenter on MacConkey agar that is β-hemolytic on SBA
Member of commensal gut flora

Classification

Has multiple pathotypes

Group	Pathotype	Serotypes	Virulence Factors	Clinical Manifestations
Extraintestinal pathogenic E. coli (ExPEC)	Uropathogenic E. coli (UPEC)			UTI
	Neonatal meningitis E. coli (NMEC)		more likely to produce K1 capsule and S fimbriae	neonatal meningitis
	Sepsis-causing E. coli (SEPEC)			bacteremia, sepsis
Intestinal pathogenic E. coli	Enteropathogenic E. coli (EPEC)	O44:H34, O55:H6/7/32, O86:H2/34, O111:H2/7/12, O114:H2, O119:H6, O124:H?, O125:H21, O127:H4/6/21, O128:H2/21, O142:H6/34, O158:H23	EPEC adherence factor, attaching/effacing changes, localized adherence pattern	severe acute watery diarrhea that can become chronic
	Enterotoxigenic E. coli (ETEC)	O6:H–/12/16/40, O8:H–/42, O25:H–/42, O27:H7, O29:H21, O63:H–/12, O78:H11/12, O117:H4, O125:H30, 0126:H2, O128:H8/35, O143:H–, O146:H39, O148:H28, O153:H45, O159:H4/21	heat-labile and -stable toxins, colonization factor antigens	acute watery diarrhea
	Enterhemorrhagic E.coli (EHEC)	O26:H11, O77:H18, O103:H2, O104:H21, O111:H8, 0113:H21, O128:H2, O145:H–, O157:H–/7, O178:H19	attaching/effacing changes, produces Stx Shiga (or related) toxins	watery and bloody diarrhea and can lead to HUS
	Shiga toxin-producing E. coli (STEC)			watery and bloody diarrhea and can lead to HUS
	Enteroaggregative E. coli (EAEC)	nontypeable, rough, O3:H2, O6:H1, O11:H16, O15:H21, O44:H18, O92:H23, O111:H21, O126:H2/27/–, O104:H4	autoaggregative attaching pattern, heat-labile and -stable toxins	mucoid diarrhea that can become chronic
	Enteroinvasive E. coli (EIEC)	O28:H–, O29:H–, O32:H–, O42:H–, O89:H–, O112:H–, O121:H–, O124:H–, O136:H–, O144:H–, O152:H–	spreads cell-to-cell (invasion factors)	watery diarrhea or dysentery
	Diffuse-adhering E. coli (DAEC)		Afa/Dr/F1845 adherence factors, invasion factors	possibly diarrhea
Animal-associated pathogenic E. coli (AAPEC)	Avian pathogenic E. coli (APEC)			bird sepsis, chronic respiratory disease, swollen head syndrome
	Mammary pathogenic E. coli (MPEC)			bovine mastitis
	Endometrial pathogenic E. coli (EnPEC)			bovine endometriosis

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Microbiology ===
+===Microbiology===
-* Lactose-fermenting [[Has Gram stain::Gram-negative]] [[Cellular shape::bacillus]] within the [[Enterobacteriaceae]]
-* Member of commensal gut flora
+*Lactose-fermenting [[Stain::Gram-negative]] [[Shape::bacillus]] within the [[Enterobacteriaceae]]
-=== Classification ===
+*Can also be non-lactose-fermenter on MacConkey agar that is β-hemolytic on SBA
-* Has multiple '''pathotypes'''
+*Member of commensal gut flora
-** '''Extraintestinal pathogenic ''E. coli'' (ExPEC):''' causes UTI and neonatal meningitis
-*** Strains that cause neonatal meningitis are more likely to produce K1 capsule and S fimbriae
-** '''Enteropathogenic ''E. coli'' (EPEC):''' produces localize adherence pilus, causes severe acute watery diarrhea that can become chronic
-** '''Enterotoxigenic ''E. coli'' (ETEC):''' produces enterotoxins, causes acute watery diarrhea
-** '''Enterhemorrhagic ''E.coli'' (EHEC) and Shiga toxin-producing ''E. coli'' (STEC):''' produces Shiga (or related) toxins, causes watery and bloody diarrhea and can lead to HUS
-** '''Enteroaggregative ''E. coli'' (EAEC):''' produces adherence factors, causes mucoid diarrhea that can become chronic
-** '''Enteroinvasive ''E. coli'' (EIEC):''' spreads cell-to-cell, causes watery diarrhea or dysentery
-** '''Diffuse-adhering ''E. coli'' (DAEC):''' causes diarrhea
+===Classification===
+*Has multiple '''pathotypes'''
+{| class="wikitable"
+!Group
+!Pathotype
+!Serotypes
+!Virulence Factors
+!Clinical Manifestations
+|-
+| rowspan="3" |Extraintestinal pathogenic ''E. coli'' (ExPEC)
+|Uropathogenic ''E. coli'' (UPEC)
+|
+|
+|[[UTI]]
+|-
+|Neonatal meningitis ''E. coli'' (NMEC)
+|
+|more likely to produce K1 capsule and S fimbriae
+|[[neonatal meningitis]]
+|-
+|Sepsis-causing ''E. coli'' (SEPEC)
+|
+|
+|[[bacteremia]], [[sepsis]]
+|-
+| rowspan="7" |Intestinal pathogenic ''E. coli''
+|Enteropathogenic ''E. coli'' (EPEC)
+|O44:H34, O55:H6/7/32, O86:H2/34, O111:H2/7/12, O114:H2, O119:H6, O124:H?, O125:H21, O127:H4/6/21, O128:H2/21, O142:H6/34, O158:H23
+|EPEC adherence factor, attaching/effacing changes, localized adherence pattern
+|severe acute watery diarrhea that can become chronic
+|-
+|Enterotoxigenic ''E. coli'' (ETEC)
+|O6:H–/12/16/40, O8:H–/42, O25:H–/42, O27:H7, O29:H21, O63:H–/12, O78:H11/12, O117:H4, O125:H30, 0126:H2, O128:H8/35, O143:H–, O146:H39, O148:H28, O153:H45, O159:H4/21
+|heat-labile and -stable toxins, colonization factor antigens
+|acute watery diarrhea
+|-
+|Enterhemorrhagic ''E.coli'' (EHEC)
+| rowspan="2" |O26:H11, O77:H18, O103:H2, O104:H21, O111:H8, 0113:H21, O128:H2, O145:H–, O157:H–/7, O178:H19
+| rowspan="2" |attaching/effacing changes, produces Stx Shiga (or related) toxins
+| rowspan="2" |watery and bloody diarrhea and can lead to HUS
+|-
+|Shiga toxin-producing ''E. coli'' (STEC)
+|-
+|Enteroaggregative ''E. coli'' (EAEC)
+|nontypeable, rough, O3:H2, O6:H1, O11:H16, O15:H21, O44:H18, O92:H23, O111:H21, O126:H2/27/–, O104:H4
+|autoaggregative attaching pattern, heat-labile and -stable toxins
+|mucoid diarrhea that can become chronic
+|-
+|Enteroinvasive ''E. coli'' (EIEC)
+|O28:H–, O29:H–, O32:H–, O42:H–, O89:H–, O112:H–, O121:H–, O124:H–, O136:H–, O144:H–, O152:H–
+|spreads cell-to-cell (invasion factors)
+|watery diarrhea or dysentery
+|-
+|Diffuse-adhering ''E. coli'' (DAEC)
+|
+|Afa/Dr/F1845 adherence factors, invasion factors
+|possibly diarrhea
+|-
+| rowspan="3" |Animal-associated pathogenic ''E. coli'' (AAPEC)
+|Avian pathogenic ''E. coli'' (APEC)
+|
+|
+|bird sepsis, chronic respiratory disease, swollen head syndrome
+|-
+|Mammary pathogenic ''E. coli'' (MPEC)
+|
+|
+|bovine mastitis
+|-
+|Endometrial pathogenic ''E. coli'' (EnPEC)
+|
+|
+|bovine endometriosis
+|}
 {{DISPLAYTITLE:''Escherichia coli''}}
 [[Category:Gram-negative bacilli]]