Rickettsia africae: Difference between revisions
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Rickettsia africae
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*Causes '''African tick-bite fever''' (ATBF) |
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*Carried by ''Amblyomma hebraeum'' and ''A. variegatum'' ticks in sub-Saharan Africa and the West Indies |
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*Most frequently-imported [[Rickettsioses|rickettsiosis]] |
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==Clinical Manifestations== |
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*Most common symptoms include fever, headache, and myalgias, with a black eschar ("tache noire") |
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**Often have regional lymphadenopathy |
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== Diagnosis == |
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* Serology is the mainstay of diagnosis, but may need paired acute and convalescent serologies demonstrating a fourfold rise in titres |
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** Compared to other [[Rickettsiae]], antibodies appear late in convalescence |
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* May see organism in skin biopsy |
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* May be able to PCR blood, skin biopsy, or eschar base swabs |
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== Management == |
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* Treated with [[Is treated by::doxycycline]] 100 mg PO bid for 7 to 10 days |
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* Alternatives include [[Is treated by::chloramphenicol]], [[Is treated by::azithromycin]], and [[Is treated by::clarithromycin]] |
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{{DISPLAYTITLE:''Rickettsia africae''}} |
{{DISPLAYTITLE:''Rickettsia africae''}} |
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[[Category:Rickettsioses]] |
[[Category:Rickettsioses]] |
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[[Category:Vector-borne infections]] |
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Latest revision as of 00:27, 19 September 2020
- Causes African tick-bite fever (ATBF)
- Carried by Amblyomma hebraeum and A. variegatum ticks in sub-Saharan Africa and the West Indies
- Most frequently-imported rickettsiosis
Clinical Manifestations
- Most common symptoms include fever, headache, and myalgias, with a black eschar ("tache noire")
- Often have regional lymphadenopathy
- Can have multiple eschars
- Rash less common
- Subacute neuropathy
Diagnosis
- Serology is the mainstay of diagnosis, but may need paired acute and convalescent serologies demonstrating a fourfold rise in titres
- Compared to other Rickettsiae, antibodies appear late in convalescence
- May see organism in skin biopsy
- May be able to PCR blood, skin biopsy, or eschar base swabs
Management
- Treated with doxycycline 100 mg PO bid for 7 to 10 days
- Alternatives include chloramphenicol, azithromycin, and clarithromycin
