Rickettsia africae: Difference between revisions
From IDWiki
Rickettsia africae
No edit summary |
No edit summary |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
* |
*Causes '''African tick-bite fever''' (ATBF) |
||
* |
*Carried by ''Amblyomma hebraeum'' and ''A. variegatum'' ticks in sub-Saharan Africa and the West Indies |
||
* |
*Most frequently-imported [[Rickettsioses|rickettsiosis]] |
||
= |
==Clinical Manifestations== |
||
*Most common symptoms include fever, headache, and myalgias, with a black eschar ("tache noire") |
|||
| ⚫ | |||
**Often have regional lymphadenopathy |
|||
| ⚫ | |||
| ⚫ | |||
| ⚫ | |||
| ⚫ | |||
| ⚫ | |||
== Diagnosis == |
|||
* Serology is the mainstay of diagnosis, but may need paired acute and convalescent serologies demonstrating a fourfold rise in titres |
|||
** Compared to other [[Rickettsiae]], antibodies appear late in convalescence |
|||
* May see organism in skin biopsy |
|||
* May be able to PCR blood, skin biopsy, or eschar base swabs |
|||
== Management == |
|||
* Treated with [[Is treated by::doxycycline]] 100 mg PO bid for 7 to 10 days |
|||
* Alternatives include [[Is treated by::chloramphenicol]], [[Is treated by::azithromycin]], and [[Is treated by::clarithromycin]] |
|||
{{DISPLAYTITLE:''Rickettsia africae''}} |
|||
[[Category:Rickettsioses]] |
[[Category:Rickettsioses]] |
||
[[Category:Vector-borne infections]] |
|||
Latest revision as of 00:27, 19 September 2020
- Causes African tick-bite fever (ATBF)
- Carried by Amblyomma hebraeum and A. variegatum ticks in sub-Saharan Africa and the West Indies
- Most frequently-imported rickettsiosis
Clinical Manifestations
- Most common symptoms include fever, headache, and myalgias, with a black eschar ("tache noire")
- Often have regional lymphadenopathy
- Can have multiple eschars
- Rash less common
- Subacute neuropathy
Diagnosis
- Serology is the mainstay of diagnosis, but may need paired acute and convalescent serologies demonstrating a fourfold rise in titres
- Compared to other Rickettsiae, antibodies appear late in convalescence
- May see organism in skin biopsy
- May be able to PCR blood, skin biopsy, or eschar base swabs
Management
- Treated with doxycycline 100 mg PO bid for 7 to 10 days
- Alternatives include chloramphenicol, azithromycin, and clarithromycin
