Cidofovir: Difference between revisions

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==Safety==
==Safety==


*Major adverse effect is [[Adverse drug reaction::irreversible renal tubular necrosis]], which may be prevented by [[probenecid]]
*Major adverse effect is irriversible [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]]
*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)
*Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)



Revision as of 23:11, 14 September 2020

Background

Spectrum of Activity

Pharmacokinetics and Pharmacodynamics

  • Unlike ganciclovir, it does not need phosphorylation by UL97
  • Does not penetrate CSF

Dosing

  • Should be given with probenecid 2 g IV prior to each dose

Safety

  • Major adverse effect is irriversible renal tubular necrosis, which may be prevented by probenecid
  • Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)