Ceftobiprole: Difference between revisions

Latest revision as of 14:05, 12 September 2020

Active against MRSA, ampicillin-susceptible Enterococcus, and penicillin-resistant Streptococcus pneumoniae, as well as aerobic Gram-negative bacteria similar to other third-generation cephalosporins
Not active against Pseudomonas, ESBL-producers, or AmpC-producers

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Mechanism of Action ===
+===Mechanism of Action===
-* Binds to and inhibits PBP-2a on MRSA
+*Binds to and inhibits PBP-2a on MRSA
-* Binds to and inhibits PBP-2x on penicillin-resistant [[Streptococcus pneumoniae]]
+*Binds to and inhibits PBP-2x on penicillin-resistant [[Streptococcus pneumoniae]]
-=== Spectrum of Activity ===
+===Spectrum of Activity===
-* Active against [[MRSA]], ampicillin-susceptible [[Enterococcus]], and penicillin-resistant [[Streptococcus pneumoniae]], as well as aerobic Gram-negative bacteria similar to other third-generation cephalosporins
+*Active against [[MRSA]], ampicillin-susceptible [[Enterococcus]], and penicillin-resistant [[Streptococcus pneumoniae]], as well as aerobic Gram-negative bacteria similar to other third-generation cephalosporins
-* Not active against [[Pseudomonas]], ESBL-producers, or AmpC-producers
+*Not active against [[Pseudomonas]], ESBL-producers, or AmpC-producers
+=== Pharmacokinetics and Pharmacodynamics ===
-== Dosing ==
+* Crosses into CSF adequately
-* Ceftobiprole 500 mg IV q8h over 2 hours
-== Safety ==
+==Dosing==
+*Ceftobiprole 500 mg IV q8h over 2 hours
-=== Adverse Drug Reactions ===
+=== Renal Dosing ===
-* Nausea, diarrhea, neutropenia (4%), dysgeusia
+* Required if CrCl <50 mL/min
+==Safety==
+===Adverse Drug Reactions===
+*Nausea, diarrhea, neutropenia (4%), dysgeusia
 [[Category:Cephalosporins]]