Leukemoid reaction: Difference between revisions

Revision as of 16:43, 26 August 2020

Background

Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy
- e.g. WBC ≥30-50 with ≥50% granulocytes

Differential Diagnosis

Infections
- Sepsis, pneumonia, urinary tract infection
- Clostridioides difficile colitis (often quite high)
- Disseminated tuberculosis
- Severe shigellosis
- Postpartum Clostridium sordellii
Inflammation
- Pancreatitis
- Mesenteric inflammatory pseudotumor
Malignancies
- Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary)
- Hodgkin lymphoma
- Melanoma
- Sarcoma
Drugs
- Corticosteroids
- Minocycline
- Recombinant hematopoietic growth factors
Miscellaneous
- Splenectomy
- Ethylene glycol intoxication
- Severe hemorrhage or acute hemolysis
- Alcoholic steatohepatitis

References

^ Vissaria Sakka, Sotirios Tsiodras, Evangelos J. Giamarellos-Bourboulis, Helen Giamarellou. An update on the etiology and diagnostic evaluation of a leukemoid reaction. European Journal of Internal Medicine. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.

@@ Line 1: / Line 1: @@
 ==Background==
-* Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy
+*Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy
-** e.g. WBC ≥30-50 with ≥50% granulocytes
+**e.g. WBC ≥30-50 with ≥50% granulocytes
 ==Differential Diagnosis==
-* '''Infections'''
+*'''Infections'''
-** [[Sepsis]], [[pneumonia]], [[urinary tract infection]]
+**[[Sepsis]], [[pneumonia]], [[urinary tract infection]]
-** ''[[Clostridioides difficile]]'' colitis (often quite high)
+**''[[Clostridioides difficile]]'' colitis (often quite high)
-** Disseminated [[tuberculosis]]
-** Severe [[shigellosis]]
+**Disseminated [[tuberculosis]]
+**Severe [[shigellosis]]
-** Postpartum ''[[Clostridium sordellii]]''
+**Postpartum ''[[Clostridium sordellii]]''
-* '''Inflammation'''
+*'''Inflammation'''
-** [[Pancreatitis]]
+**[[Pancreatitis]]
-** Mesenteric inflammatory pseudotumor
+**Mesenteric inflammatory pseudotumor
-* '''Malignancies'''
+*'''Malignancies'''
-** Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary)
+**Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary)
-** Hodgkin lymphoma
+**[[Hodgkin lymphoma]]
-** Melanoma
+**[[Melanoma]]
-** Sarcoma
+**[[Sarcoma]]
-* '''Drugs'''
+*'''Drugs'''
-** Corticosteroids
+**[[Corticosteroids]]
-** Minocycline
+**[[Minocycline]]
-** Recombinant hematopoietic growth factors
+**Recombinant hematopoietic growth factors
-* '''Miscellaneous'''
+*'''Miscellaneous'''
-** [[Splenectomy]]
+**[[Splenectomy]]
-** Ethylene glycol intoxication
+**[[Ethylene glycol intoxication]]
-** Severe hemorrhage or acute hemolysis
+**Severe hemorrhage or acute [[hemolysis]]
-** Alcoholic steatohepatitis
+**[[Alcoholic steatohepatitis]]
 ==Further Reading==
-* Leukemoid reaction: Spectrum and prognosis of 173 adult patients. ''Clin Infect Dis''. 2013;57:e177. doi: [https://doi.org/10.1093/cid/cit562 10.1093/cid/cit562]
-* An update on the etiology and diagnostic evaluation of a leukemoid reaction. ''Eur J Internal Med''. 2006 Oct;17(6):394-8. doi: [https://doi.org/10.1016/j.ejim.2006.04.004 10.1016/j.ejim.2006.04.004]
+*Leukemoid reaction: Spectrum and prognosis of 173 adult patients. ''Clin Infect Dis''. 2013;57:e177. doi: [https://doi.org/10.1093/cid/cit562 10.1093/cid/cit562]
+*An update on the etiology and diagnostic evaluation of a leukemoid reaction. ''Eur J Internal Med''. 2006 Oct;17(6):394-8. doi: [https://doi.org/10.1016/j.ejim.2006.04.004 10.1016/j.ejim.2006.04.004]