Escherichia coli: Difference between revisions

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Escherichia coli
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*Has multiple '''pathotypes'''
  
*Has multiple '''pathotypes'''
⚫
**'''Extraintestinal pathogenic ''E. coli'' (ExPEC):''' causes UTI and neonatal meningitis
  
⚫
***Strains that cause neonatal meningitis are more likely to produce K1 capsule and S fimbriae
  
−
**'''Enteropathogenic ''E. coli'' (EPEC):''' produces localize adherence pilus, causes severe acute watery diarrhea that can become chronic
  
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**'''Enterotoxigenic ''E. coli'' (ETEC):''' produces enterotoxins, causes acute watery diarrhea
  
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**'''Enterhemorrhagic ''E.coli'' (EHEC) and Shiga toxin-producing ''E. coli'' (STEC):''' produces Shiga (or related) toxins, causes watery and bloody diarrhea and can lead to HUS
  
−
**'''Enteroaggregative ''E. coli'' (EAEC):''' produces adherence factors, causes mucoid diarrhea that can become chronic
  
−
**'''Enteroinvasive ''E. coli'' (EIEC):''' spreads cell-to-cell, causes watery diarrhea or dysentery
  
⚫
**'''Diffuse-adhering ''E. coli'' (DAEC):''' causes diarrhea
  
   
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{| class="wikitable"
  +
!Group
  +
!Pathotype
  +
!Serotypes
  +
!Virulence Factors
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!Clinical Manifestations
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|-
  ⚫
| rowspan="3" |Extraintestinal pathogenic ''E. coli'' (ExPEC)
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|Uropathogenic ''E. coli'' (UPEC)
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|
  +
|
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|[[UTI]]
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|-
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|Neonatal meningitis ''E. coli'' (NMEC)
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|
  ⚫
|more likely to produce K1 capsule and S fimbriae
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|[[neonatal meningitis]]
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|-
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|Sepsis-causing ''E. coli'' (SEPEC)
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|
  +
|
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|[[bacteremia]], [[sepsis]]
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|-
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| rowspan="7" |Intestinal pathogenic ''E. coli''
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|Enteropathogenic ''E. coli'' (EPEC)
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|O44:H34, O55:H6/7/32, O86:H2/34, O111:H2/7/12, O114:H2, O119:H6, O124:H?, O125:H21, O127:H4/6/21, O128:H2/21, O142:H6/34, O158:H23
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|EPEC adherence factor, attaching/effacing changes, localized adherence pattern
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|severe acute watery diarrhea that can become chronic
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|-
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|Enterotoxigenic ''E. coli'' (ETEC)
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|O6:H–/12/16/40, O8:H–/42, O25:H–/42, O27:H7, O29:H21, O63:H–/12, O78:H11/12, O117:H4, O125:H30, 0126:H2, O128:H8/35, O143:H–, O146:H39, O148:H28, O153:H45, O159:H4/21
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|heat-labile and -stable toxins, colonization factor antigens
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|acute watery diarrhea
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|-
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|Enterhemorrhagic ''E.coli'' (EHEC)
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| rowspan="2" |O26:H11, O77:H18, O103:H2, O104:H21, O111:H8, 0113:H21, O128:H2, O145:H–, O157:H–/7, O178:H19
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| rowspan="2" |attaching/effacing changes, produces Stx Shiga (or related) toxins
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| rowspan="2" |watery and bloody diarrhea and can lead to HUS
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|-
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|Shiga toxin-producing ''E. coli'' (STEC)
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|-
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|Enteroaggregative ''E. coli'' (EAEC)
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|nontypeable, rough, O3:H2, O6:H1, O11:H16, O15:H21, O44:H18, O92:H23, O111:H21, O126:H2/27/–, O104:H4
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|autoaggregative attaching pattern, heat-labile and -stable toxins
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|mucoid diarrhea that can become chronic
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|-
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|Enteroinvasive ''E. coli'' (EIEC)
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|O28:H–, O29:H–, O32:H–, O42:H–, O89:H–, O112:H–, O121:H–, O124:H–, O136:H–, O144:H–, O152:H–
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|spreads cell-to-cell (invasion factors)
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|watery diarrhea or dysentery
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|-
  ⚫
|Diffuse-adhering ''E. coli'' (DAEC)
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|
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|Afa/Dr/F1845 adherence factors, invasion factors
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|diarrhea
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|-
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| rowspan="3" |Animal-associated pathogenic ''E. coli'' (AAPEC)
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|Avian pathogenic ''E. coli'' (APEC)
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|
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|
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|bird sepsis, chronic respiratory disease, swollen head syndrome
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|-
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|Mammary pathogenic ''E. coli'' (MPEC)
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|
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|
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|bovine mastitis
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|-
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|Endometrial pathogenic ''E. coli'' (EnPEC)
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|
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|
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|bovine endometriosis
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|}
 
{{DISPLAYTITLE:''Escherichia coli''}}
  
{{DISPLAYTITLE:''Escherichia coli''}}
 
[[Category:Gram-negative bacilli]]
  
[[Category:Gram-negative bacilli]]

Revision as of 20:23, 22 August 2020

Background

Microbiology

  • Lactose-fermenting Gram-negative bacillus within the Enterobacteriaceae
  • Can also be non-lactose-fermenter on MacConkey agar that is β-hemolytic on SBA
  • Member of commensal gut flora

Classification

  • Has multiple pathotypes
Group Pathotype Serotypes Virulence Factors Clinical Manifestations
Extraintestinal pathogenic E. coli (ExPEC) Uropathogenic E. coli (UPEC) UTI
Neonatal meningitis E. coli (NMEC) more likely to produce K1 capsule and S fimbriae neonatal meningitis
Sepsis-causing E. coli (SEPEC) bacteremia, sepsis
Intestinal pathogenic E. coli Enteropathogenic E. coli (EPEC) O44:H34, O55:H6/7/32, O86:H2/34, O111:H2/7/12, O114:H2, O119:H6, O124:H?, O125:H21, O127:H4/6/21, O128:H2/21, O142:H6/34, O158:H23 EPEC adherence factor, attaching/effacing changes, localized adherence pattern severe acute watery diarrhea that can become chronic
Enterotoxigenic E. coli (ETEC) O6:H–/12/16/40, O8:H–/42, O25:H–/42, O27:H7, O29:H21, O63:H–/12, O78:H11/12, O117:H4, O125:H30, 0126:H2, O128:H8/35, O143:H–, O146:H39, O148:H28, O153:H45, O159:H4/21 heat-labile and -stable toxins, colonization factor antigens acute watery diarrhea
Enterhemorrhagic E.coli (EHEC) O26:H11, O77:H18, O103:H2, O104:H21, O111:H8, 0113:H21, O128:H2, O145:H–, O157:H–/7, O178:H19 attaching/effacing changes, produces Stx Shiga (or related) toxins watery and bloody diarrhea and can lead to HUS
Shiga toxin-producing E. coli (STEC)
Enteroaggregative E. coli (EAEC) nontypeable, rough, O3:H2, O6:H1, O11:H16, O15:H21, O44:H18, O92:H23, O111:H21, O126:H2/27/–, O104:H4 autoaggregative attaching pattern, heat-labile and -stable toxins mucoid diarrhea that can become chronic
Enteroinvasive E. coli (EIEC) O28:H–, O29:H–, O32:H–, O42:H–, O89:H–, O112:H–, O121:H–, O124:H–, O136:H–, O144:H–, O152:H– spreads cell-to-cell (invasion factors) watery diarrhea or dysentery
Diffuse-adhering E. coli (DAEC) Afa/Dr/F1845 adherence factors, invasion factors diarrhea
Animal-associated pathogenic E. coli (AAPEC) Avian pathogenic E. coli (APEC) bird sepsis, chronic respiratory disease, swollen head syndrome
Mammary pathogenic E. coli (MPEC) bovine mastitis
Endometrial pathogenic E. coli (EnPEC) bovine endometriosis
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