Fluconazole: Difference between revisions

Revision as of 16:16, 21 August 2020

Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida

Good oral bioavailability
Good CNS penetration
Fungistatic
Efficacy predicted by AUC/MIC ratio
Susceptibility breakpoints for Candida albicans are:
- Susceptible MIC ≤2
- Susceptible dose-dependent MIC 4
- Resistant MIC ≥8

Best side effect profiles of the antifungals
Before starting, check:
- Liver enzymes as baseline (hepatitis)
- Creatinine (requires renal dosing)
- EKG (QTc prolongation)
Beware drug-drug interactions, especially with new DOACs

@@ Line 3: / Line 3: @@
 *Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of ''Candida''
-=== Pharmacokinetics and Pharmacodynamics ===
+===Pharmacokinetics and Pharmacodynamics===
-* Good oral bioavailability
+*Good oral bioavailability
-* Good CNS penetration
+*Good CNS penetration
-* Fungistatic
+*Fungistatic
+*Efficacy predicted by AUC/MIC ratio
-* Susceptibility breakpoints for [[Candida albicans]] are:
+*Susceptibility breakpoints for [[Candida albicans]] are:
-** Susceptible MIC ≤2
-** Susceptible dose-dependent MIC 4
+**Susceptible MIC ≤2
-** Resistant MIC ≥8
+**Susceptible dose-dependent MIC 4
+**Resistant MIC ≥8
 ==Monitoring==