Fluconazole: Difference between revisions

Revision as of 16:16, 21 August 2020

Background

Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida

Pharmacokinetics and Pharmacodynamics

Good oral bioavailability
Good CNS penetration
Fungistatic
Susceptibility breakpoints for Candida albicans are:
- Susceptible MIC ≤2
- Susceptible dose-dependent MIC 4
- Resistant MIC ≥8

Monitoring

ECG for QT prolongation
Liver enzymes for hepatitis

Adverse Drug Reactions

Best side effect profiles of the antifungals
Before starting, check:
- Liver enzymes as baseline (hepatitis)
- Creatinine (requires renal dosing)
- EKG (QTc prolongation)
Beware drug-drug interactions, especially with new DOACs

@@ Line 1: / Line 1: @@
+==Background==
-== Classification ==
-* Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of ''Candida''
+*Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of ''Candida''
+=== Pharmacokinetics and Pharmacodynamics ===
-== Indications ==
+* Good oral bioavailability
-* Fungal infections
+* Good CNS penetration
+* Fungistatic
+* Susceptibility breakpoints for [[Candida albicans]] are:
+** Susceptible MIC ≤2
+** Susceptible dose-dependent MIC 4
+** Resistant MIC ≥8
-== Monitoring ==
+==Monitoring==
-* ECG for QT prolongation
+*ECG for QT prolongation
-* Liver enzymes for hepatitis
+*Liver enzymes for hepatitis
+==Adverse Drug Reactions==
-== Pharmacokinetics ==
-* Good oral bioavailability
-* CNS penetration
+*Best side effect profiles of the antifungals
-== Adverse Drug Reactions ==
+*Before starting, check:
-* Best side effect profiles of the antifungals
+**Liver enzymes as baseline ([[Adverse drug reaction::hepatitis]])
-* Before starting, check:
+**Creatinine (requires renal dosing)
-** Liver enzymes as baseline ([[Adverse drug reaction::hepatitis]])
+**EKG ([[Adverse drug reaction::QTc prolongation]])
-** Creatinine (requires renal dosing)
-** EKG ([[Adverse drug reaction::QTc prolongation]])
+*Beware [[Adverse drug reaction::drug-drug interactions]], especially with new DOACs
-* Beware [[Adverse drug reaction::drug-drug interactions]], especially with new DOACs
 [[Category:Antifungals]]