Escherichia coli: Difference between revisions

Revision as of 13:59, 20 August 2020

Background

Microbiology

Lactose-fermenting Gram-negative bacillus within the Enterobacteriaceae
Can also be non-lactose-fermenter on MacConkey agar that is β-hemolytic on SBA
Member of commensal gut flora

Classification

Has multiple pathotypes
- Extraintestinal pathogenic E. coli (ExPEC): causes UTI and neonatal meningitis
  - Strains that cause neonatal meningitis are more likely to produce K1 capsule and S fimbriae
- Enteropathogenic E. coli (EPEC): produces localize adherence pilus, causes severe acute watery diarrhea that can become chronic
- Enterotoxigenic E. coli (ETEC): produces enterotoxins, causes acute watery diarrhea
- Enterhemorrhagic E.coli (EHEC) and Shiga toxin-producing E. coli (STEC): produces Shiga (or related) toxins, causes watery and bloody diarrhea and can lead to HUS
- Enteroaggregative E. coli (EAEC): produces adherence factors, causes mucoid diarrhea that can become chronic
- Enteroinvasive E. coli (EIEC): spreads cell-to-cell, causes watery diarrhea or dysentery
- Diffuse-adhering E. coli (DAEC): causes diarrhea

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Microbiology ===
+===Microbiology===
-* Lactose-fermenting [[Stain::Gram-negative]] [[Cellular shape::bacillus]] within the [[Enterobacteriaceae]]
-* Member of commensal gut flora
+*Lactose-fermenting [[Stain::Gram-negative]] [[Cellular shape::bacillus]] within the [[Enterobacteriaceae]]
-=== Classification ===
+*Can also be non-lactose-fermenter on MacConkey agar that is β-hemolytic on SBA
-* Has multiple '''pathotypes'''
+*Member of commensal gut flora
-** '''Extraintestinal pathogenic ''E. coli'' (ExPEC):''' causes UTI and neonatal meningitis
-*** Strains that cause neonatal meningitis are more likely to produce K1 capsule and S fimbriae
+===Classification===
-** '''Enteropathogenic ''E. coli'' (EPEC):''' produces localize adherence pilus, causes severe acute watery diarrhea that can become chronic
-** '''Enterotoxigenic ''E. coli'' (ETEC):''' produces enterotoxins, causes acute watery diarrhea
+*Has multiple '''pathotypes'''
-** '''Enterhemorrhagic ''E.coli'' (EHEC) and Shiga toxin-producing ''E. coli'' (STEC):''' produces Shiga (or related) toxins, causes watery and bloody diarrhea and can lead to HUS
-** '''Enteroaggregative ''E. coli'' (EAEC):''' produces adherence factors, causes mucoid diarrhea that can become chronic
+**'''Extraintestinal pathogenic ''E. coli'' (ExPEC):''' causes UTI and neonatal meningitis
+***Strains that cause neonatal meningitis are more likely to produce K1 capsule and S fimbriae
-** '''Enteroinvasive ''E. coli'' (EIEC):''' spreads cell-to-cell, causes watery diarrhea or dysentery
-** '''Diffuse-adhering ''E. coli'' (DAEC):''' causes diarrhea
+**'''Enteropathogenic ''E. coli'' (EPEC):''' produces localize adherence pilus, causes severe acute watery diarrhea that can become chronic
+**'''Enterotoxigenic ''E. coli'' (ETEC):''' produces enterotoxins, causes acute watery diarrhea
+**'''Enterhemorrhagic ''E.coli'' (EHEC) and Shiga toxin-producing ''E. coli'' (STEC):''' produces Shiga (or related) toxins, causes watery and bloody diarrhea and can lead to HUS
+**'''Enteroaggregative ''E. coli'' (EAEC):''' produces adherence factors, causes mucoid diarrhea that can become chronic
+**'''Enteroinvasive ''E. coli'' (EIEC):''' spreads cell-to-cell, causes watery diarrhea or dysentery
+**'''Diffuse-adhering ''E. coli'' (DAEC):''' causes diarrhea
 {{DISPLAYTITLE:''Escherichia coli''}}