Spinal epidural abscess

Background

• Infection of the epidural space, between the dura mater and bone
• May be intracranial or spinal, with spinal being far more common
• Acquired from contiguous spread (e.g. discitis, otitis media/sinusitis/mastoiditis, direct inoculation (e.g. spinal anaesthesia or neurosurgery), or hematogenous spread
• Risk factors include intravenous drug use, hemodialysis, diabetes mellitus, and older age

Microbiology

• Staphylococcus aureus is most common cause

Clinical Manifestations

• Severe low-back pain often worse with palpation
• Fever
• Malaise
• Neurologic deficits associated with mass effect on spinal cord, interruption of arterial supply, venous thrombosis, or toxin

Diagnosis

• Usually made by MRI (or CT with contrast)
• Blood cultures may be helpful
• Cultures from the abscess fluid, if possible

Management

• May need urgent neurosurgical drainage if neurological symptoms
• Intravenous antibiotics, ideally after blood cultures are drawn
• Typical empiric antibiotics are ceftriaxone and vancomycin