Chronic granulomatous disease: Difference between revisions
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Revision as of 19:32, 15 August 2020
Background
- Primary immunodeficiency of neutrophils leading to recurrent infections with catalase-positive organisms
Pathophysiology
- Defect in NADPH oxidase
- Therefore unable to generate superoxide radicals required by phagocytes to kill pathogens
Clinical Manifestations
- Recurrent infections with catalase-positive organisms, including Staphylococcus aureus
- Highest-risk group for invasive aspergillosis
Management
- Treat intercurrent infections
- Prophylaxis with:
- TMP-SMX
- Itraconazole
- Possibly also interferon-γ
