Bacterial meningitis (IDSA 2004): Difference between revisions

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== Table 4: Empiric Treatment ==
==Table 4: Empiric Treatment==


{| class="wikitable"
{|
! Population
!Population
! Common pathogens
!Common pathogens
! Antimicrobial therapy
!Antimicrobial therapy
|-
|-
| Age
! colspan="3" |Age
|
|
|-
|-
| <1 month
|<1 month
| GBS, E.coli, Listeria, Klebsiella
|[[Group B streptococcus]], [[Escherichia coli]], [[Listeria]], [[Klebsiella]]
| amp + cefotax, or<br/>amp + AG
|amp + cefotax, or<br />amp + AG
|-
|-
| 1-23 months
|1-23 months
|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Group B streptococcus]], [[Haemophilus influenzae]], [[Escherichia coli]]
| S.pneumo, N.mening, GBS, H.flu, E.coli
| vanco + 3G ceph
|vanco + 3G ceph
|-
|-
| 2-50 years
|2-50 years
|[[Neisseria meningitidis]], [[Streptococcus pneumoniae]]
| N.mening, S.pneumo
| vanco + 3G ceph
|vanco + 3G ceph
|-
|-
| &gt;50 years
|&gt;50 years
|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Listeria]], [[Gram-negative bacilli]]
| S.pneumo, N.mining, Listeria, GNBs
| vanco + 3G ceph + amp
|vanco + 3G ceph + amp
|-
|-
| Head trauma
! colspan="3" |Head trauma
|
|
|-
|-
| Basilar skull fracture
|Basilar skull fracture
|[[Streptococcus pneumoniae]], [[Haemophilus influenzae]], [[GAS]]
| S.pneumo, H.flu, GAS
| vanco + 3G ceph
|vanco + 3G ceph
|-
|-
| Penetrating trauma
|Penetrating trauma
|[[Staphylococcus aureus]], [[coagulase-negative staphylococci]], [[Gram-negative bacilli]]
| Staph.aureus, CoNS, GNBs
| vanco + cefep, or<br/>vanco + ceftaz, or<br/>vanco + mero
|vanco + cefep, or<br />vanco + ceftaz, or<br />vanco + mero
|-
|-
| Post-neurosurgery
|Post-neurosurgery
|[[Gram-negative bacilli]], [[Staphylococcus aureus]], [[coagulase-negative staphylococci]]
| GNBs, Staph.aureus, CoNS
| vanco + cefep, or<br/>vanco + ceftaz, or<br/>vanco + mero
|vanco + cefep, or<br />vanco + ceftaz, or<br />vanco + mero
|-
|-
| CSF shunt
|CSF shunt
|[[Coagulase-negative staphylococci]], [[Staphylococcus aureus]], [[Gram-negative bacilli]], [[Cutibacterium acnes]]
| CoNS, Staph,aureus, GNBs, P.acnes
| vanco + cefep, or<br/>vanco + ceftaz, or<br/>vanco + mero
|vanco + cefep, or<br />vanco + ceftaz, or<br />vanco + mero
|}
|}



Latest revision as of 19:51, 2 August 2020

Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004 Nov 1;39(9):1267-84. Epub 2004 Oct 6. doi: 10.1086/425368


Table 4: Empiric Treatment

Population Common pathogens Antimicrobial therapy
Age
<1 month Group B streptococcus, Escherichia coli, Listeria, Klebsiella amp + cefotax, or
amp + AG
1-23 months Streptococcus pneumoniae, Neisseria meningitidis, Group B streptococcus, Haemophilus influenzae, Escherichia coli vanco + 3G ceph
2-50 years Neisseria meningitidis, Streptococcus pneumoniae vanco + 3G ceph
>50 years Streptococcus pneumoniae, Neisseria meningitidis, Listeria, Gram-negative bacilli vanco + 3G ceph + amp
Head trauma
Basilar skull fracture Streptococcus pneumoniae, Haemophilus influenzae, GAS vanco + 3G ceph
Penetrating trauma Staphylococcus aureus, coagulase-negative staphylococci, Gram-negative bacilli vanco + cefep, or
vanco + ceftaz, or
vanco + mero
Post-neurosurgery Gram-negative bacilli, Staphylococcus aureus, coagulase-negative staphylococci vanco + cefep, or
vanco + ceftaz, or
vanco + mero
CSF shunt Coagulase-negative staphylococci, Staphylococcus aureus, Gram-negative bacilli, Cutibacterium acnes vanco + cefep, or
vanco + ceftaz, or
vanco + mero