Paracoccidioides brasiliensis: Difference between revisions
From IDWiki
Paracoccidioides brasiliensis
m (Aidan moved page Dimorphic to Paracoccidioides brasiliensis without leaving a redirect) |
m (Text replacement - "Clinical Presentation" to "Clinical Manifestations") |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
| ⚫ | |||
== Microbiology == |
== Microbiology == |
||
| Line 12: | Line 10: | ||
* Has been isolated from the feces of bats (''Artibeus lituratus'') and from internal organs of the nine-banded armadillo |
* Has been isolated from the feces of bats (''Artibeus lituratus'') and from internal organs of the nine-banded armadillo |
||
== Clinical |
== Clinical Manifestations == |
||
* Usually self-limited pulmonary infection |
* Usually self-limited pulmonary infection |
||
| Line 31: | Line 29: | ||
== Management == |
== Management == |
||
* Itraconazole 200 to 400 mg/day for 9 to 12 months |
* [[Is treated by::Itraconazole]] 200 to 400 mg/day for 9 to 12 months |
||
* If severe, consider amphotericin 1mg/kg/day |
* If severe, consider [[Is treated by::amphotericin B]] 1mg/kg/day |
||
* ?Septra |
* ?Septra |
||
| ⚫ | |||
[[Category:Dimorphic fungi]] |
|||
Latest revision as of 14:23, 20 July 2020
Microbiology
- Dimorphic fungus with four phylogenetic lineages
- Disease is caused by P. brasiliensis and P. lutzii (newly discovered)
- Mariner's wheel of budding conidia
Epidemiology
- South and Central America, with Brazil being the largest endemic country
- Has been isolated from the feces of bats (Artibeus lituratus) and from internal organs of the nine-banded armadillo
Clinical Manifestations
- Usually self-limited pulmonary infection
- Can cause acute/subacute pulmonary infection in children, adolescents, and immunocompromised individuals
- Fever, weight loss, lymphadenopathy, and hepatosplenomegaly
- Half have skin and mucosal lesions
- Can cause chronic disease in adults
- Pulmonary infiltrates on CXR
- Adrenal lesions with insufficiency are common
- However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease
Diagnosis
- Serology
- Antibodies
- Antigen
Management
- Itraconazole 200 to 400 mg/day for 9 to 12 months
- If severe, consider amphotericin B 1mg/kg/day
- ?Septra
