Post-transplant acute limbic encephalitis: Difference between revisions
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* Caused by [[HHV-6B]][[CiteRef::ongrádi2016ro]] |
* Caused by [[HHV-6B]][[CiteRef::ongrádi2016ro]] |
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== Clinical |
== Clinical Manifestations == |
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* Onset 2 weeks to 2 months after transplant |
* Onset 2 weeks to 2 months after transplant |
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* Presents with confusion, amnesia, hallucinations |
* Presents with confusion, amnesia, hallucinations |
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Latest revision as of 17:07, 19 July 2020
- Limbic encephalitis syndrome following hematopoietic stem cell transplantation
Background
Clinical Manifestations
- Onset 2 weeks to 2 months after transplant
- Presents with confusion, amnesia, hallucinations
- Can cause seizures
- Hyponatremia is common
Management
- Treat seizures with antiepileptic medications
- Treat any possible concomitant risk factors such as hyponytremia
- Antivirals: acyclovir, ganciclovir, or foscarnet for 10 days to 4 weeks
Further Reading
- Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology. 2007;69(2):156-165. DOI: 10.1212/01.wnl.0000265591.10200.d7
References
- ^ Joseph Ongrádi, Dharam V. Ablashi, Tetsushi Yoshikawa, Balázs Stercz, Masao Ogata. Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals. Journal of NeuroVirology. 2016;23(1):1-19. doi:10.1007/s13365-016-0473-0.
