Fever in a hospitalized patient: Difference between revisions
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= Fever in the hospitalized patient = |
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* Core temperature >38.3ºC |
* Core temperature >38.3ºC |
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= Pathophysiology = |
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* Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds |
* Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds |
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* Decoupling of oxidative phosphorylation, as in drug-induced |
* Decoupling of oxidative phosphorylation, as in drug-induced |
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= Differential Diagnosis = |
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* Infectious |
* Infectious |
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** Traumatic brain injury or ischemic brain injury |
** Traumatic brain injury or ischemic brain injury |
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** Endocrine fever |
** Endocrine fever |
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Revision as of 11:47, 13 August 2019
Definition
- Core temperature >38.3ºC
Pathophysiology
- Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds
- Either direct action or cytokine production that stimulates the organum vasculosum of the lamina terminalis (OVLT) in the hypothalamus
- Neurogenic
- Decoupling of oxidative phosphorylation, as in drug-induced
Differential Diagnosis
- Infectious
- Non-infectious
- Inflammatory diseases
- Drug-induced, including ß-lactam antibiotics, sulphonamides, antipsychotics, propofol
- Traumatic brain injury or ischemic brain injury
- Endocrine fever
