Adult-onset Still's disease: Difference between revisions
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** TNF receptor associated periodic syndrome (TRAPS) |
** TNF receptor associated periodic syndrome (TRAPS) |
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== Clinical |
== Clinical Manifestations == |
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* Sore throat |
* Sore throat |
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Revision as of 23:28, 14 July 2020
Definition
- Inflammatory condition of unknown etiology characterized by fever, rash, and arthritis
Differential Diagnosis
- Reactive arthritis
- Other spondyloarthropathies
- Haemophagocytic syndrome
- Dermatomyositis
- Kikuchi syndrome
- Sweet syndrome
- Granulomatous disorders
- Vasculitis
- Periodic fever syndromes
- Familial Mediterranean fever
- TNF receptor associated periodic syndrome (TRAPS)
Clinical Manifestations
- Sore throat
- Myalgia
- Fever over 39°C, transient, lasting typically under 4 hours
- Arthritis: usually knees, wrists, and ankles
- Arthralgia
- Lymphadenopathy
- Rash: evanescent, salmon‐pink, maculopapular eruption, predominantly found on the proximal limbs and trunk
- Splenomegaly
- Pleuritis
- Pericarditis
Investigations
- RF and ANA negative
- Elevated ferritin >1000
- Leukocytosis, anemia, thrombocytosis
- Elevated liver enzymes and LDH
Management
- NSAIDs, steroids, and antirheumatic agents
