Hepatitis A virus: Difference between revisions

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(added incubation period)
m (Text replacement - "Clinical Presentation" to "Clinical Manifestations")
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* Most often linked to travel or to household contacts
 
* Most often linked to travel or to household contacts
   
== Clinical Presentation ==
+
== Clinical Manifestations ==
 
* Incubation period is from 15 to 50 days, with an average of 28 days
 
* Incubation period is from 15 to 50 days, with an average of 28 days
   

Revision as of 19:22, 14 July 2020

Background

Microbiology

  • Non-enveloped RNA virus within the Picornavirus family
  • Three genotypes, I through III
  • Difficult to kill: needs higher temperatures and lower pH than other viruses, or bleach- or ammonium-based cleaners

Epidemiology

  • Fecal-oral transmission with person-to-person spread (including sex)
  • Can be transmitted by contaminated food and water, as well
  • Most often linked to travel or to household contacts

Clinical Manifestations

  • Incubation period is from 15 to 50 days, with an average of 28 days

Diagnosis

Serology

IgM IgG Interpretation
No recent infection (unless in the incubation period). No prior infection or vaccination.
+ No infection. Prior infection or vaccination.
? + Cannot rule out active infection. Prior infection or vaccination.
+ +/– Acute or recent infection. IgM positive from 2 weeks until 3-12 months. IgG positive from 8-12 weeks and remains positive for lifetime.

References

  1. ^  J. T. Stapleton. Host Immune Response To Hepatitis A Virus. Journal of Infectious Diseases. 1995;171(Supplement 1):S9-S14. doi:10.1093/infdis/171.supplement_1.s9.