Severe inflammatory response syndrome

Definition

• SIRS requires two or more of the following:
  • Temperature >38 or <36
  • Heart rate >90
  • Respiratory rate >20 or PaCO2 <32
  • WBC >12k or <4k, or bands >10%
• Sepsis is SIRS with a suspected infection
• Severe sepsis is sepsis with end-organ dysfunction
  • Elevated lactate
  • Decreased urine output
  • Elevated creatinine
  • Elevated INR
• Septic shock is sepsis with shock despite adequate resuscitation