Polycythemia vera

WHO Criteria

• Major criteria
  • Polycythemia, as evidenced by one of:
    • Hemoglobin >16.5 g/dL in men or >16.0 g/dL in women
    • Hematocrit >49% in men or >48% in women
    • Increased red cell mass more than 25% above reference range
  • Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic, and megakaryocytic proliferation with pleomorphic, mature megakaryocytes (differences in size)
  • Presence of JAK2 V617F or JAK2 exon 12 mutation
• Minor criterion
  • Subnormal serum erythropoietin level
• Diagnosis of PV requires meeting either all 3 major criteria, or the first 2 major criteria and the minor criterion¶