Chronic myeloid leukemia

Clinical Presentation

• Triphasic: chronic phase, accelerated phase, and blast crisis
• Almost half are asymptomatic on diagnosis
• Prsenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
• Often have splenomegaly, which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
• Can present with anemia, very elevated WBCs, and elevated platelets