Balamuthia mandrillaris: Difference between revisions
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Balamuthia mandrillaris
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** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality |
** Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality |
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** Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness |
** Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness |
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| − | * Often preceded by skin lesions |
+ | * Often preceded by skin lesions by a few weeks to 2 years |
| + | ** Typically affect the nose and cheeks, but also torso and limbs |
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| + | ** Often a single lesion |
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| + | ** Progress over months from papulonodular erythematous plate-like areas, enlarging and eventually ulcerating |
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| + | ** Typically painless |
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| + | * Can also initially present with rhinitis, sinusitis, or otitis media |
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* Difficult to treat, with high mortality |
* Difficult to treat, with high mortality |
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Revision as of 22:18, 3 June 2020
Background
Microbiology
- One of the free-living amoebae
Epidemiology
- Present in soil
- More common in US and South America
- More common in Hispanics
Clinical Presentation
- Causes granulomatous amebic encephalitis (GAE) alone, skin lesions followed by GAE, or (rarely) skin lesions alone
- Characterized by progressive hemorrhagic necrosis of brain, with 90% mortality
- Fever, headache, altered mentation), vomiting, lethargy, seizures, and weakness
- Often preceded by skin lesions by a few weeks to 2 years
- Typically affect the nose and cheeks, but also torso and limbs
- Often a single lesion
- Progress over months from papulonodular erythematous plate-like areas, enlarging and eventually ulcerating
- Typically painless
- Can also initially present with rhinitis, sinusitis, or otitis media
- Difficult to treat, with high mortality
