Leukemoid reaction: Difference between revisions
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** Disseminated [[tuberculosis]] |
** Disseminated [[tuberculosis]] |
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** Severe [[shigellosis]] |
** Severe [[shigellosis]] |
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** Postpartum ''[[Clostridium sordellii]]'' |
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* '''Inflammation''' |
* '''Inflammation''' |
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** [[Pancreatitis]] |
** [[Pancreatitis]] |
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Revision as of 23:36, 3 June 2020
Background
- Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy
- e.g. WBC ≥30-50 with ≥50% granulocytes
Differential Diagnosis
- Infections
- Sepsis, pneumonia, urinary tract infection
- Clostridioides difficile colitis (often quite high)
- Disseminated tuberculosis
- Severe shigellosis
- Postpartum Clostridium sordellii
- Inflammation
- Pancreatitis
- Mesenteric inflammatory pseudotumor
- Malignancies
- Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary)
- Hodgkin lymphoma
- Melanoma
- Sarcoma
- Drugs
- Corticosteroids
- Minocycline
- Recombinant hematopoietic growth factors
- Miscellaneous
- Splenectomy
- Ethylene glycol intoxication
- Severe hemorrhage or acute hemolysis
- Alcoholic steatohepatitis
Further Reading
- Leukemoid reaction: Spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57:e177. doi: 10.1093/cid/cit562
- An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Internal Med. 2006 Oct;17(6):394-8. doi: 10.1016/j.ejim.2006.04.004
