SPICE organisms: Difference between revisions
From IDWiki
(Imported from text file) |
mNo edit summary |
||
| Line 1: | Line 1: | ||
= |
= Definition = |
||
== Definition == |
|||
* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC |
* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC |
||
= Organisms = |
|||
* ''Serratia'' spp. |
* ''Serratia'' spp. |
||
| Line 17: | Line 15: | ||
* ''Hafnia alvei'' |
* ''Hafnia alvei'' |
||
* ''Acinetobacter'', though not inducible or AmpC |
* ''Acinetobacter'', though not inducible or AmpC (merely very resistant_ |
||
* ''Morganella morganii'' |
* ''Morganella morganii'' |
||
* ''Cronobacter'' |
* ''Cronobacter'' |
||
* ''Edwardsiella'' |
* ''Edwardsiella'' |
||
= Treatment = |
|||
* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days |
* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days |
||
* Carbapenems still work, as do aminoglycosides |
* Carbapenems still work, as do aminoglycosides |
||
= Further Reading = |
|||
* Jones R, Baquero F, Privitera G, Inoue M, Widermann B. [https://doi.org/10.1111/j.1469-0691.1997.tb00643.x Inducible β-lactamase-mediated resistance to third-generation cephalosporins]. ''Clin Microbio Infect''. 1997;3(1):S7-S20. |
* Jones R, Baquero F, Privitera G, Inoue M, Widermann B. [https://doi.org/10.1111/j.1469-0691.1997.tb00643.x Inducible β-lactamase-mediated resistance to third-generation cephalosporins]. ''Clin Microbio Infect''. 1997;3(1):S7-S20. |
||
* [https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz173/5369903 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz173/5369903] |
* [https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz173/5369903 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz173/5369903] |
||
[[Category:Gram-negative bacilli]] |
|||
Revision as of 11:27, 12 August 2019
Definition
- Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC
Organisms
- Serratia spp.
- Providencia
- Indole-positive Proteae (e.g. Proteus vulgaris, but not Proteus mirabilis)
- Citrobacter spp.
- C. koseri does not have an AmpC
- Enterobacter cloacae
Also:
- Hafnia alvei
- Acinetobacter, though not inducible or AmpC (merely very resistant_
- Morganella morganii
- Cronobacter
- Edwardsiella
Treatment
- Not penicillins or cephalosporins, as resistance will develop within a few days
- Carbapenems still work, as do aminoglycosides
Further Reading
- Jones R, Baquero F, Privitera G, Inoue M, Widermann B. Inducible β-lactamase-mediated resistance to third-generation cephalosporins. Clin Microbio Infect. 1997;3(1):S7-S20.
- https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz173/5369903
