Dientamoeba fragilis: Difference between revisions
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Dientamoeba fragilis
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== Background == |
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=== Microbiology === |
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* Gastrointestinal flagellated protozoan parasite |
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=== Life Cycle === |
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* Unclear, but may inoculate humans via [[pinworm]] eggs |
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== Clinical Presentation == |
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* There exists some debate about its pathogenicity |
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* Many cases are asymptomatic and incidental on stool ova & parasite |
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* Attributable symptoms, when present, vague abdominal pain, bloating, diarrhea, fatigue, weight loss and anorexia |
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== Management == |
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* Look for coinfection with ''[[Enterobius vermicularis]]'' |
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* If symptomatic, treat with: |
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** [[Is treated by::Iodoquinol]] 650 mg orally three times daily for 20 days |
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** [[Is treated by::Paromomycin]] 25–35 mg per kg per day orally, in three divided doses, for 7 days |
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** [[Is treated by::Metronidazole]] 500–750 mg orally three times daily for 10 days, though this may be associated with a higher rate of recurrence |
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== Further Reading == |
== Further Reading == |
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* ''Dientamoeba fragilis'', the Neglected Trichomonad of the Human Bowel. ''Clin Microbiol Rev''. 2016;29(3):553–580. DOI: [https://doi.org/10.1128/CMR.00076-15 10.1128/CMR.00076-15] |
* ''Dientamoeba fragilis'', the Neglected Trichomonad of the Human Bowel. ''Clin Microbiol Rev''. 2016;29(3):553–580. DOI: [https://doi.org/10.1128/CMR.00076-15 10.1128/CMR.00076-15] |
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Revision as of 16:20, 25 February 2020
Background
Microbiology
- Gastrointestinal flagellated protozoan parasite
Life Cycle
- Unclear, but may inoculate humans via pinworm eggs
Clinical Presentation
- There exists some debate about its pathogenicity
- Many cases are asymptomatic and incidental on stool ova & parasite
- Attributable symptoms, when present, vague abdominal pain, bloating, diarrhea, fatigue, weight loss and anorexia
Management
- Look for coinfection with Enterobius vermicularis
- If symptomatic, treat with:
- Iodoquinol 650 mg orally three times daily for 20 days
- Paromomycin 25–35 mg per kg per day orally, in three divided doses, for 7 days
- Metronidazole 500–750 mg orally three times daily for 10 days, though this may be associated with a higher rate of recurrence
Further Reading
- Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel. Clin Microbiol Rev. 2016;29(3):553–580. DOI: 10.1128/CMR.00076-15
- Dientamoeba fragilis: A harmless commensal or a mild pathogen? Paed Child Health. 1998;3(2):81-82. DOI: 10.1093/pch/3.2.81
- A Review of the Clinical Presentation of Dientamoebiasis. Am J Trop Med Hyg. 2010;82(4):614-619. DOI: 10.4269/ajtmh.2010.09-0478
