Pyrimethamine: Difference between revisions
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* Indications include [[Is treatment for::toxoplasmosis]] and [[Is treatment for::malaria]] |
* Indications include [[Is treatment for::toxoplasmosis]] and [[Is treatment for::malaria]] |
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* Major adverse effects is bone marrow suppression, so need to monitor CBC |
* Major adverse effects is bone marrow suppression, so need to monitor CBC |
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** Pancytopenia, which is reversible with leucovorin |
** [[Adverse drug reaction::Pancytopenia]], which is reversible with leucovorin |
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** GI intolerance |
** [[Adverse drug reaction::GI intolerance]] |
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** Other: rash, hepatitis, headache, dizziness, insomnia |
** Other: [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::headache]], [[Adverse drug reaction::dizziness]], [[Adverse drug reaction::insomnia]] |
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* Monitoring |
* Monitoring |
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** CBC q2d initially, then decreasing frequency |
** CBC q2d initially, then decreasing frequency |
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Revision as of 03:20, 18 February 2020
- Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid
- Indications include toxoplasmosis and malaria
- Major adverse effects is bone marrow suppression, so need to monitor CBC
- Pancytopenia, which is reversible with leucovorin
- GI intolerance
- Other: rash, hepatitis, headache, dizziness, insomnia
- Monitoring
- CBC q2d initially, then decreasing frequency
