Congenital CMV: Difference between revisions
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* Mother may have had asymptomatic infection |
* Mother may have had asymptomatic infection |
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* At birth |
* At birth |
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** Microcephaly |
** [[Causes::Microcephaly]] |
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** Periventricular calcifications |
** [[Causes::Periventricular calcifications]] |
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** Chorioretinitis |
** [[Causes::Chorioretinitis]] |
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** Sensorineural hearing loss |
** [[Causes::Sensorineural hearing loss]] |
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** Optic nerve atrophy |
** [[Causes::Optic nerve atrophy]] |
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** Hepatosplenomegaly |
** [[Causes::Hepatosplenomegaly]] |
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** [[Causes::Cytopenias]] |
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** Cytopenia |
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* Later |
* Later |
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** Cognitive deficits (7%) |
** [[Causes::Cognitive deficits]] (7%) |
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** Sensorineural hearing loss (20%) |
** [[Causes::Sensorineural hearing loss]] (20%) |
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== Diagnosis == |
== Diagnosis == |
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Revision as of 15:07, 8 February 2020
Epidemiology
- Risk of transmission to fetus
- Primary infection: 30% risk of congenital CMV; higher risk later in pregnancy, but worse outcomes earlier
- Non-primary
- Reinfection: 5% risk
- Reactivation: 1% risk
Clinical Presentation
- Mother may have had asymptomatic infection
- At birth
- Later
- Cognitive deficits (7%)
- Sensorineural hearing loss (20%)
Diagnosis
- In mom, IgM antibodies
- In baby, urine PCR within 2 weeks of birth
Management
- Treatment is indicated for symptomatic babies
- Brain
- Hearing
- Eye
- IV ganciclovir or PO valganciclovir, for 6 months
- Monitor CBC while on therapy
References
- ^ Gisela Enders, Anja Daiminger, Ursula Bäder, Simone Exler, Martin Enders. Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age. Journal of Clinical Virology. 2011;52(3):244-246. doi:10.1016/j.jcv.2011.07.005.
- ^ William D Rawlinson, Suresh B Boppana, Karen B Fowler, David W Kimberlin, Tiziana Lazzarotto, Sophie Alain, Kate Daly, Sara Doutré, Laura Gibson, Michelle L Giles, Janelle Greenlee, Stuart T Hamilton, Gail J Harrison, Lisa Hui, Cheryl A Jones, Pamela Palasanthiran, Mark R Schleiss, Antonia W Shand, Wendy J van Zuylen. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. The Lancet Infectious Diseases. 2017;17(6):e177-e188. doi:10.1016/s1473-3099(17)30143-3.
