Β-lactamases: Difference between revisions
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Β-lactamases
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== Classification == |
== Classification == |
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* Class A |
* '''Class A''' |
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** Constitutively expressed plasmid |
** Constitutively expressed plasmid |
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** Most common ESBL in Gram-negative bacteria |
** Most common ESBL in Gram-negative bacteria |
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** Resistance to 2nd and 3rd generation cephalosporins |
** Resistance to 2nd and 3rd generation cephalosporins |
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** Common in ''E. coli'', ''Klebsiella'', and ''Proteus'' spp. |
** Common in ''E. coli'', ''Klebsiella'', and ''Proteus'' spp. |
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* Class |
* '''Class B''': metallobetalactamases |
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* '''Class C''': ampC |
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** Inducible AmpC gene present in the genome |
** Inducible AmpC gene present in the genome |
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** Common in ''Citrobacter'', ''Serratia'', and ''Enterobacter'' |
** Common in ''Citrobacter'', ''Serratia'', and ''Enterobacter'' |
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* '''Class D''': OXA |
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== Management == |
== Management == |
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Revision as of 22:19, 1 February 2020
Definition
- Bacteria containing a plasmid that codes for an extended-spectrum beta-lactamase (ESBL)
- Most common with Escherichia coli and Klebsiella
Classification
- Class A
- Constitutively expressed plasmid
- Most common ESBL in Gram-negative bacteria
- Resistance to 2nd and 3rd generation cephalosporins
- Common in E. coli, Klebsiella, and Proteus spp.
- Class B: metallobetalactamases
- Class C: ampC
- Inducible AmpC gene present in the genome
- Common in Citrobacter, Serratia, and Enterobacter
- Class D: OXA
Management
- Antibiotic therapy tailored to the resistance pattern
- Carbapenems, aminoglycosides, fluoroquinolones, and Septra typically work well
References
- ^ R. Cantón, M.I. Morosini, O. Martin, S. de la Maza, E. Gomez G. de la Pedrosa. IRT and CMT β-lactamases and inhibitor resistance. Clinical Microbiology and Infection. 2008;14:53-62. doi:10.1111/j.1469-0691.2007.01849.x.
