Β-lactam resistance: Difference between revisions
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Β-lactam resistance
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* Class C: AmpC ß-lactamases |
* Class C: AmpC ß-lactamases |
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* Class D: OXA ß-lactamases |
* Class D: OXA ß-lactamases |
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== Specific ß-lactamases == |
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=== NDM-1 === |
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* Broad-spectrum metallo-beta-lactamase and carbapenemase |
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* Can be treated empirically with [[ceftazadime-avibactam]] and [[aztreonam]] +/- [[colistin]] |
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[[Category:Antibiotics]] |
[[Category:Antibiotics]] |
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Revision as of 22:33, 15 November 2019
Mechanisms
- ß-lactamase production: enzymatic breakdown of beta lactam antibiotic
- Penicillin binding protein mutations (e.g. MRSA)
- Efflux pump mutations
- Porin channel mutations that reduce antibiotic influx
Ambler Classification of ß-lactamases
- Based on amino acid sequences rather than function
- Classes A, C, and D are serine ß-lactamases
- Class A: original active-site serine ß-lactamases
- Class B: original metallo-ß-lactamases
- Class C: AmpC ß-lactamases
- Class D: OXA ß-lactamases
Specific ß-lactamases
NDM-1
- Broad-spectrum metallo-beta-lactamase and carbapenemase
- Can be treated empirically with ceftazadime-avibactam and aztreonam +/- colistin
