Streptococcus pneumoniae: Difference between revisions
From IDWiki
Streptococcus pneumoniae
m (added category) |
(added Pathophysiology) |
||
| Line 10: | Line 10: | ||
* Major cause of morbidity and mortality in children |
* Major cause of morbidity and mortality in children |
||
** Leading cause of under-5 mortality worldwide |
** Leading cause of under-5 mortality worldwide |
||
== Pathophysiology == |
|||
* Acquired by coughing and sneezing |
|||
* Asymptomatic carriage or colonization in the nasopharynx |
|||
* Invasion through epithelial cells into the bloodstream, using the PAF and pIg receptors |
|||
* Capsule and various proteins help it to evade immune system |
|||
{{DISPLAYTITLE:''Streptococcus pneumoniae''}} |
{{DISPLAYTITLE:''Streptococcus pneumoniae''}} |
||
Revision as of 22:32, 2 October 2019
Microbiology
- Gram-positive, lancet-shaped diplococci
- 90+ serotypes, based on capsular polysaccharide that is bound to peptidoglycan
- Lab identification is based on α-hemolysis of blood agar (from pneumolysin), optochin susceptibility, and bile salt solubility
Epidemiology
- Present worldwide
- Major cause of morbidity and mortality in children
- Leading cause of under-5 mortality worldwide
Pathophysiology
- Acquired by coughing and sneezing
- Asymptomatic carriage or colonization in the nasopharynx
- Invasion through epithelial cells into the bloodstream, using the PAF and pIg receptors
- Capsule and various proteins help it to evade immune system
