Pyrimethamine: Difference between revisions

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** GI intolerance
** GI intolerance
** Other: rash, hepatitis, headache, dizziness, insomnia
** Other: rash, hepatitis, headache, dizziness, insomnia
* Monitoring
** CBC q2d initially, then decreasing frequency

Revision as of 14:03, 19 September 2019

  • Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid
  • Indications include toxoplasmosis and malaria
  • Major adverse effects is bone marrow suppression, so need to monitor CBC
    • Pancytopenia, which is reversible with leucovorin
    • GI intolerance
    • Other: rash, hepatitis, headache, dizziness, insomnia
  • Monitoring
    • CBC q2d initially, then decreasing frequency