HIV-hepatitis C coinfection: Difference between revisions
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= Principles = |
== Principles == |
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* Confirm both diagnoses, including ensuring HCV RNA is still positive 6 months after first measured |
* Confirm both diagnoses, including ensuring HCV RNA is still positive 6 months after first measured |
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* Treat the HIV for at least 2 weeks before starting HCV treatment |
* Treat the HIV for at least 2 weeks before starting HCV treatment |
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= Regimens = |
== Regimens == |
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* Consult [https://www.hep-druginteractions.org/checker HEP Drug Interactions checker] |
* Consult [https://www.hep-druginteractions.org/checker HEP Drug Interactions checker] |
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* Be careful with Harvoni, which can increase levels of tenofovir, especially when GFR <60 mL/min |
* Be careful with Harvoni, which can increase levels of tenofovir, especially when GFR <60 mL/min |
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= Further Reading = |
== Further Reading == |
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* [https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv/26/hcv-hiv "Considerations for Antiretroviral Use in Patients with Coinfections"], in ''Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV''. AIDSinfo. |
* [https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv/26/hcv-hiv "Considerations for Antiretroviral Use in Patients with Coinfections"], in ''Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV''. AIDSinfo. |
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Revision as of 15:11, 17 August 2019
Principles
- Confirm both diagnoses, including ensuring HCV RNA is still positive 6 months after first measured
- Treat the HIV first, using any first-line regimen
- Treat the HIV for at least 2 weeks before starting HCV treatment
Regimens
- Consult HEP Drug Interactions checker
- Be careful with Harvoni, which can increase levels of tenofovir, especially when GFR <60 mL/min
Further Reading
- "Considerations for Antiretroviral Use in Patients with Coinfections", in Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. AIDSinfo.
- "Patients With HIV/HCV Coinfection", in HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. IDSA & AASLD.
