SPICE organisms: Difference between revisions
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= Definition = |
== Definition == |
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* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC |
* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC |
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= Organisms = |
== Organisms == |
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* ''Serratia'' spp. |
* ''Serratia'' spp. |
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* ''Edwardsiella'' |
* ''Edwardsiella'' |
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= Treatment = |
== Treatment == |
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* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days |
* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days |
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* Carbapenems still work, as do aminoglycosides |
* Carbapenems still work, as do aminoglycosides |
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= Further Reading = |
== Further Reading == |
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* Jones R, Baquero F, Privitera G, Inoue M, Widermann B. [https://doi.org/10.1111/j.1469-0691.1997.tb00643.x Inducible β-lactamase-mediated resistance to third-generation cephalosporins]. ''Clin Microbio Infect''. 1997;3(1):S7-S20. |
* Jones R, Baquero F, Privitera G, Inoue M, Widermann B. [https://doi.org/10.1111/j.1469-0691.1997.tb00643.x Inducible β-lactamase-mediated resistance to third-generation cephalosporins]. ''Clin Microbio Infect''. 1997;3(1):S7-S20. |
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Revision as of 12:50, 16 August 2019
Definition
- Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC
Organisms
- Serratia spp.
- Providencia
- Indole-positive Proteae (e.g. Proteus vulgaris, but not Proteus mirabilis)
- Citrobacter spp.
- C. koseri does not have an AmpC
- Enterobacter cloacae
Also:
- Hafnia alvei
- Acinetobacter, though not inducible or AmpC (merely very resistant_
- Morganella morganii
- Cronobacter
- Edwardsiella
Treatment
- Not penicillins or cephalosporins, as resistance will develop within a few days
- Carbapenems still work, as do aminoglycosides
Further Reading
- Jones R, Baquero F, Privitera G, Inoue M, Widermann B. Inducible β-lactamase-mediated resistance to third-generation cephalosporins. Clin Microbio Infect. 1997;3(1):S7-S20.
- https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz173/5369903
