Complement deficiency: Difference between revisions
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|Early (C1, C2, and C4) |
|Early (C1, C2, and C4) |
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|Encapsulated bacterial infections like [[Streptococcus pneumoniae]] and [[Haemophilus influenzae]] type b. Higher risk of autoimmune diseases, particularly [[systemic lupus erythematosus]] |
|Encapsulated bacterial infections like [[Streptococcus pneumoniae]] and [[Haemophilus influenzae]] type b. Higher risk of autoimmune diseases, particularly [[systemic lupus erythematosus]]. |
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|Early (C3) |
|Early (C3) |
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Latest revision as of 15:31, 9 February 2026
Background
- Group of primary or acquired immunodeficiencies affecting the complement system within the innate humoural immune system
- Usually autosomal recessive genetic diseases
- Commonly defined as early (C1-C4) or late (C5-C9)
Clinical Manifestations
| Deficiency | |
|---|---|
| Early (C1, C2, and C4) | Encapsulated bacterial infections like Streptococcus pneumoniae and Haemophilus influenzae type b. Higher risk of autoimmune diseases, particularly systemic lupus erythematosus. |
| Early (C3) | Severe recurrent pyogenic infections early in life |
| Late (C5-C9) | Recurrent Neisseria infections |
| Alternative (properdin) | Recurrent Neisseria infections |
| Mannan-binding lectin | Increase frequency of pyogenic infections, particularly in young children |
