Alkaline phosphatase: Difference between revisions
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Created page with "== Background == * Serum marker from biliary tract, bone, and placenta * In bone, it indicates high bone turnover, which can be from a number of causes: healing fractures, osteomalacia, hyperparathyroidism, hyperthyroidism, Paget disease of bone, osteogenic sarcoma, and bone metastases" |
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== Background == |
== Background == |
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* Group of isoenzymes that catalyzes hydrolysis of organic phosphate esters in the extracellular space |
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* Found in liver, bone, placenta, ileal mucosa, and kidney |
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* Can be tissue-specific or tissue-nonspecific, the latter of which makes up most of the serum ALP |
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== Interpretation == |
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* Serum marker from biliary tract, bone, and placenta |
* Serum marker from biliary tract, bone, and placenta |
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* In bone, it indicates high bone turnover, which can be from a number of causes: healing fractures, [[osteomalacia]], [[hyperparathyroidism]], [[hyperthyroidism]], [[Paget disease of bone]], [[osteogenic sarcoma]], and bone metastases |
* In bone, it indicates high bone turnover, which can be from a number of causes: healing fractures, [[osteomalacia]], [[hyperparathyroidism]], [[hyperthyroidism]], [[Paget disease of bone]], [[osteogenic sarcoma]], and bone metastases |
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* Hemolysis, jaundice, and high lipids can interfere with testing |
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* Many things affect serum ALP |
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** Decrease serum ALP: [[clofibrate]] |
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** Increase serum ALP: lots and lots, including [[verapamil]] |
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=== Isoenzymes === |
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* Electrophoresis can separate into liver, bone, placental, and intestinal fractions |
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** Liver and bone are hard to separate |
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[[Category:Diagnostic tests]] |
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Latest revision as of 14:30, 6 October 2025
Background
- Group of isoenzymes that catalyzes hydrolysis of organic phosphate esters in the extracellular space
- Found in liver, bone, placenta, ileal mucosa, and kidney
- Can be tissue-specific or tissue-nonspecific, the latter of which makes up most of the serum ALP
Interpretation
- Serum marker from biliary tract, bone, and placenta
- In bone, it indicates high bone turnover, which can be from a number of causes: healing fractures, osteomalacia, hyperparathyroidism, hyperthyroidism, Paget disease of bone, osteogenic sarcoma, and bone metastases
- Hemolysis, jaundice, and high lipids can interfere with testing
- Many things affect serum ALP
- Decrease serum ALP: clofibrate
- Increase serum ALP: lots and lots, including verapamil
Isoenzymes
- Electrophoresis can separate into liver, bone, placental, and intestinal fractions
- Liver and bone are hard to separate
