Drug-induced thrombocytopenia: Difference between revisions
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Created page with "* Typical onset 5 to 10 days after drug administration ** Nadir of less than 20 ** A severe form is heparin-induced thrombocytopenia, discussed elsewhere ** Counts usually start to recover after 4 or 5 half-lives of the offending medication * IVIG can be given in severe thrombocytopenia * Drugs associated with non-immune thrombocytopenia ** Impaired thrombopoiesis: chemotherapy, interferon-alpha, linezolid, botrezomib, thiazide diuretics, ethanol, tolbutamid, g..." |
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Latest revision as of 20:46, 29 September 2025
- Typical onset 5 to 10 days after drug administration
- Nadir of less than 20
- A severe form is heparin-induced thrombocytopenia, discussed elsewhere
- Counts usually start to recover after 4 or 5 half-lives of the offending medication
- IVIG can be given in severe thrombocytopenia
- Drugs associated with non-immune thrombocytopenia
- Impaired thrombopoiesis: chemotherapy, interferon-alpha, linezolid, botrezomib, thiazide diuretics, ethanol, tolbutamid, ganciclovir
- Platelet apoptosis: tamoxifen, navitoclax, methotrexate, nuclear factor-kB inhibitors, lovastatin, doxorubicin, bexarotene, arsenic trioxide, aspirin, vancomycin, trifluoperazine, balhimycin, carmustine, cisplatin
- Other drugs:
- Quinine, sulfonamide, NSAIDs
- Penicillin, some cephalosporins
- Tirofiban, eptifibatide
- Abciximab
- Gold salts, procainamide
- Heparin, protamine
