Meropenem-vaborbactam: Difference between revisions
From IDWiki
Content deleted Content added
Created page with "== Background == === Mechanism of Activity === * Vaborbactam is active against KPC carbapenemases == Safety == === Monitoring === * Seizures, thrombocytopenia, drug inter..." |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 4: | Line 4: | ||
* Vaborbactam is active against KPC carbapenemases |
* Vaborbactam is active against KPC carbapenemases |
||
== Dosing == |
|||
* Carbapenem-resistant infection with [[Enterobacterales]]: 4 g IV every 8 hours |
|||
* Complicated [[urinary tract infection]]: 4 g IV every 8 hours for 5 to 14 days |
|||
=== Renal Dosing === |
|||
{| class="wikitable" |
|||
!eGFR |
|||
!Dose |
|||
|- |
|||
|≥50 |
|||
|4 g IV every 8 hours (normal dose) |
|||
|- |
|||
|30 to 49 |
|||
|2 g IV every 8 hours |
|||
|- |
|||
|15 to 29 |
|||
|2 g IV every 12 hours |
|||
|- |
|||
|<15 |
|||
|1 g IV every 12 hours |
|||
|- |
|||
|IHD |
|||
|1 g IV every 12 hours |
|||
|- |
|||
|PD |
|||
|1 g IV every 12 hours |
|||
|- |
|||
|CRRT |
|||
|2 g IV every 8 hours |
|||
|} |
|||
== Safety == |
== Safety == |
||
Latest revision as of 16:09, 27 June 2025
Background
Mechanism of Activity
- Vaborbactam is active against KPC carbapenemases
Dosing
- Carbapenem-resistant infection with Enterobacterales: 4 g IV every 8 hours
- Complicated urinary tract infection: 4 g IV every 8 hours for 5 to 14 days
Renal Dosing
| eGFR | Dose |
|---|---|
| ≥50 | 4 g IV every 8 hours (normal dose) |
| 30 to 49 | 2 g IV every 8 hours |
| 15 to 29 | 2 g IV every 12 hours |
| <15 | 1 g IV every 12 hours |
| IHD | 1 g IV every 12 hours |
| PD | 1 g IV every 12 hours |
| CRRT | 2 g IV every 8 hours |
Safety
Monitoring
- Seizures, thrombocytopenia, drug interaction with valproic acid
