Macrocytic anemia: Difference between revisions
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Created page with "== Background == * Anemia with elevated mean corpuscular volume (MCV) above 100 fL == Etiologies == * Megaloblastic (hypersegmented neutrophils suggesting impaired DNA synthesis) ** Vitamin B12 deficiency ** Folate deficiency ** Methotrexate effect * Non-megaloblastic ** Alcohol consumption ** Hereditary spherocytosis ** Hypothyroidism ** Liver disease ** Reticulocytosis from bleeding or hemolysis * May be seen in infants, patients with Dow..." |
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** [[Folate deficiency]] |
** [[Folate deficiency]] |
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** [[Methotrexate]] effect |
** [[Methotrexate]] effect |
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** [[Myelodysplastic syndrome]] |
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* Non-megaloblastic |
* Non-megaloblastic |
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** Alcohol consumption |
** Alcohol consumption |
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Latest revision as of 19:03, 20 June 2025
Background
- Anemia with elevated mean corpuscular volume (MCV) above 100 fL
Etiologies
- Megaloblastic (hypersegmented neutrophils suggesting impaired DNA synthesis)
- Non-megaloblastic
- Alcohol consumption
- Hereditary spherocytosis
- Hypothyroidism
- Liver disease
- Reticulocytosis from bleeding or hemolysis
- May be seen in infants, patients with Down syndrome, and pregnant women
- Extreme macrocytosis greater than 130 fL is sometimes seen with zidovudine, stavudine, and lamivudine
