Eosinophilic granulomatosis with polyantiitis: Difference between revisions
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Created page with "== Background == * Small-vessel ANCA-associated vasculitis * Also known as Churg-Strauss disease == Clinical Manifestations == * Thought to follow separate stages, though there is overlap: ** Prodromal phase, with atopy, allergic rhinitis, asthma, chronic rhinosinusitis ** Eosinophilic phase, with peripheral eosinophilia (greater than 0.5), with a mean eosinophil count of 7.5 ** Vasculitic phase, with the development of end-organ damage f..." |
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* Peripheral neuropathy (mononeuritis multiplex) (75%) |
* Peripheral neuropathy (mononeuritis multiplex) (75%) |
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* Kidney injury (25%) |
* Kidney injury (25%) |
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* Eosinophilic gastritis or enteritis, with abdominal pain ( |
* Eosinophilic gastritis or enteritis, with abdominal pain (60%), diarrhea (30%), GI bleed (20%) |
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* Myalgias and arthralgias and even arthritis (40-50%) |
* Myalgias and arthralgias and even arthritis (40-50%) |
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* |
* Lymphadenopathy (30-40%) |
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[[Category:Rheumatology]] |
[[Category:Rheumatology]] |
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Latest revision as of 17:22, 5 May 2025
Background
- Small-vessel ANCA-associated vasculitis
- Also known as Churg-Strauss disease
Clinical Manifestations
- Thought to follow separate stages, though there is overlap:
- Prodromal phase, with atopy, allergic rhinitis, asthma, chronic rhinosinusitis
- Eosinophilic phase, with peripheral eosinophilia (greater than 0.5), with a mean eosinophil count of 7.5
- Vasculitic phase, with the development of end-organ damage from vasculitis, often with fevers, malaise, and weight loss
- Asthma (90%), which precedes vasculitis by around 10 years
- Allergic rhinitis, recurrent sinusitis, nasal polyposis, nasal obstruction, characterized by nasal discharge (90%), congestion (85%), facial pain/pressure (85%)
- Skin involvement during the vasculitic phase, with tender subcutaneous nodules particularly on the elbows, hands, and legs
- Peripheral neuropathy (mononeuritis multiplex) (75%)
- Kidney injury (25%)
- Eosinophilic gastritis or enteritis, with abdominal pain (60%), diarrhea (30%), GI bleed (20%)
- Myalgias and arthralgias and even arthritis (40-50%)
- Lymphadenopathy (30-40%)
