Corynebacterium: Difference between revisions
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Corynebacterium
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*Genus of [[Stain::Gram-positive]] club-shaped [[Shape::bacillus|bacilli]] that form characteristic "Chinese letter" patterns on stain |
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* Includes: |
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** [[Corynebacterium striatum]] |
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** [[Corynebacterium jeikeium]] |
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** [[Corynebacterium diphtheriae]] |
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** [[Corynebacterium pseudotuberculosis]] |
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** [[Corynebacterium amycolatum]] |
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** [[Corynebacterium urealyticum]] |
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{| class="wikitable" |
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{{DISPLAYTITLE:''Corynebacterium'' species}} |
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!Species |
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!Diseases |
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!Resistance |
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! colspan="3" |''Corynebacterium'' Species |
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|[[Corynebacterium afermentans]] subsp. ''afermentans'' |
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|[[CLABSI]] |
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|[[Corynebacterium amycolatum]] |
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|[[healthcare-associated pneumonia]], [[CLABSI]], [[native valve endocarditis]], [[prosthetic valve endocarditis]], [[skin and soft tissue infection]], [[surgical site infection]] |
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|[[Corynebacterium confusum]] |
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|[[skin and soft tissue infection]] |
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|[[Corynebacterium diphtheriae]] |
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|[[diphtheria]], [[myocarditis]] |
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|[[Corynebacterium glucuronolyticum]] |
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|[[genitourinary infection]], [[chronic prostatitis]] |
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|[[Corynebacterium jeikeium]] |
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|[[ventricular shunt infection]], nosocomial [[meningitis]], [[CLABSI]], [[native valve endocarditis]], [[prosthetic valve endocarditis]], [[surgical site infection]], [[prosthetic joint infection]], [[CAPD]] [[peritonitis]] |
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|mostly resistant to beta lactams, macrolides, and aminoglycosides |
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|[[Corynebacterium kroppenstedtii]] |
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|breast [[abscess]] |
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|[[Corynebacterium macginleyi]] |
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|[[conjunctivitis]], [[keratitis]], [[CLABSI]] |
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|[[Corynebacterium minutissimum]] |
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|[[skin and soft tissue infection]], breast [[abscess]], [[CLABSI]], [[surgical site infection]] |
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|[[Corynebacterium propinquum]] |
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|[[conjunctivitis]], [[keratitis]], [[native valve endocarditis]] |
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|[[Corynebacterium pseudodiphtheriticum]] |
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|[[conjunctivitis]], [[keratitis]], [[pharyngitis]], [[native valve endocarditis]], [[healthcare-associated pneumonia]] |
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|[[Corynebacterium pseudotuberculosis]] |
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|[[lymphadenitis]], [[skin and soft tissue infection]] |
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|may exhibit erm-mediated resistance to [[clindamycin]] and [[macrolides]] |
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|[[Corynebacterium riegelii]] |
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|[[genitourinary infection]] |
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|[[Corynebacterium striatum]] |
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|[[native joint infection]], [[healthcare-associated pneumonia]], [[CLABSI]], [[native valve endocarditis]], [[prosthetic valve endocarditis]], [[surgical site infection]] |
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|may exhibit erm-mediated resistance to [[clindamycin]] and [[macrolides]] |
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|[[Corynebacterium tuberculostearicum]] |
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|breast [[abscess]] |
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|[[Corynebacterium ulcerans]] |
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|[[diphtheria]], [[pharyngitis]], [[skin and soft tissue infection]] |
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|[[Corynebacterium urealyticum]] |
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|[[healthcare-associated pneumonia]], [[CLABSI]], [[native valve endocarditis]], [[skin and soft tissue infection]], [[surgical site infection]], [[UTI]], [[CAPD]] [[peritonitis]] |
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|mostly resistant to beta lactams, macrolides, and aminoglycosides |
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! colspan="3" |Other Coryneform Bacteria |
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|[[Arcanobacterium haemolyticum]] |
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|[[pharyngitis]], [[peritonsillar abscess]], [[odontogenic infection]], [[skin and soft tissue infection]], [[native valve endocarditis]] |
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|[[Brevibacterium]] |
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|nosocomial [[meningitis]], [[CAPD]] [[peritonitis]] |
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|[[Brevibacterium casei]] |
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|[[CLABSI]], [[prosthetic valve endocarditis]] |
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|[[Cellulosimicrobium]] |
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|[[Dermabacter]] |
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|[[CAPD]] [[peritonitis]] |
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|[[Microbacterium]] |
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|[[CLABSI]] |
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|[[Oerskovia]] |
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|[[CLABSI]] |
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|[[Rothia dentocariosa]] |
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|[[odontogenic infection]], [[native valve endocarditis]], [[CAPD]] [[peritonitis]] |
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|[[Trueperella bernardiae]] |
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|[[CLABSI]] |
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|[[Trueperella pyogenes]] |
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|[[skin and soft tissue infection]], [[CLABSI]] |
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|} |
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== Management == |
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* The only reliable treatment options are [[vancomycin]], [[daptomycin]], and [[linezolid]][[CiteRef::neemuchwala2018in]] |
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** [[Tetracycline]] and [[TMP-SMX]] are sometimes options depending on the species and isolate |
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** See also [[CiteRef::neemuchwala2018in]] for a recent summary of susceptibilities in Ontario |
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{| class="wikitable" |
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|+Susceptibilities (in %) in Ontario 2011-2016[[CiteRef::neemuchwala2018]] |
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!Species |
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!PEN |
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!ERY |
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!CLI |
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!CIP |
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!MXF |
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!TET |
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!VAN |
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!SXT |
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!RIF |
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!Q-D |
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!LZD |
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!GEN |
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!DAP |
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|- |
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|''Corynebacterium'' spp. |
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|15 |
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|15 |
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|9 |
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|27 |
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|28 |
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|64 |
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|100 |
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|38 |
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|91 |
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|93 |
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|100 |
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|93 |
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|98 |
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|[[Corynebacterium striatum]] |
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|0.1 |
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|15 |
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|5 |
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|5 |
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|5 |
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|35 |
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|100 |
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|12 |
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|86 |
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|99 |
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|100 |
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|93 |
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|98 |
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|[[Corynebacterium amycolatum]] |
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|11 |
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|16 |
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|21 |
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|27 |
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|27 |
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|86 |
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|100 |
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|67 |
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|98 |
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|100 |
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|100 |
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|93 |
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|100 |
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|[[Corynebacterium pseudodiphtheriticum]]/[[Corynebacterium propinquum]] |
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|96 |
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|21 |
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|21 |
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|79 |
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|79 |
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|99 |
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|100 |
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|88 |
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|100 |
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|100 |
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|100 |
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|100 |
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|100 |
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|- |
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|[[Corynebacterium afermentans]] subsp. afermentans |
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|1 |
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|0 |
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|0 |
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|30 |
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|32 |
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|88 |
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|100 |
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|55 |
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|94 |
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|52 |
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|100 |
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|99 |
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|98 |
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|[[Corynebacterium jeikeium]] |
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|0 |
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|12 |
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|3 |
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|36 |
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|36 |
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|92 |
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|100 |
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|18 |
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|97 |
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|90 |
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|100 |
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|82 |
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|90 |
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|[[Corynebacterium minutissimum]] |
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|4 |
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|20 |
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|1 |
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|55 |
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|62 |
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|92 |
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|100 |
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|62 |
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|96 |
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|93 |
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|99 |
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|97 |
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|92 |
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|[[Corynebacterium coyleae]] |
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|2 |
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|4 |
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|4 |
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|28 |
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|29 |
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|93 |
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|100 |
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|48 |
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|91 |
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|43 |
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|100 |
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|100 |
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|93 |
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|[[Corynebacterium urealyticum]] |
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|4 |
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|2 |
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|4 |
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|4 |
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|4 |
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|92 |
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|100 |
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|2 |
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|92 |
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|100 |
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|100 |
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|56 |
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|100 |
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|[[Corynebacterium aurimucosum]] |
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|6 |
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|12 |
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|0 |
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|43 |
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|43 |
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|90 |
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|100 |
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|63 |
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|100 |
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|92 |
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|100 |
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|100 |
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|98 |
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|} |
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{{DISPLAYTITLE:''Corynebacterium''}} |
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[[Category:Gram-positive bacilli]] |
[[Category:Gram-positive bacilli]] |
Latest revision as of 02:15, 14 November 2024
- Genus of Gram-positive club-shaped bacilli that form characteristic "Chinese letter" patterns on stain
Management
- The only reliable treatment options are vancomycin, daptomycin, and linezolid1
- Tetracycline and TMP-SMX are sometimes options depending on the species and isolate
- See also 1 for a recent summary of susceptibilities in Ontario
Species | PEN | ERY | CLI | CIP | MXF | TET | VAN | SXT | RIF | Q-D | LZD | GEN | DAP |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corynebacterium spp. | 15 | 15 | 9 | 27 | 28 | 64 | 100 | 38 | 91 | 93 | 100 | 93 | 98 |
Corynebacterium striatum | 0.1 | 15 | 5 | 5 | 5 | 35 | 100 | 12 | 86 | 99 | 100 | 93 | 98 |
Corynebacterium amycolatum | 11 | 16 | 21 | 27 | 27 | 86 | 100 | 67 | 98 | 100 | 100 | 93 | 100 |
Corynebacterium pseudodiphtheriticum/Corynebacterium propinquum | 96 | 21 | 21 | 79 | 79 | 99 | 100 | 88 | 100 | 100 | 100 | 100 | 100 |
Corynebacterium afermentans subsp. afermentans | 1 | 0 | 0 | 30 | 32 | 88 | 100 | 55 | 94 | 52 | 100 | 99 | 98 |
Corynebacterium jeikeium | 0 | 12 | 3 | 36 | 36 | 92 | 100 | 18 | 97 | 90 | 100 | 82 | 90 |
Corynebacterium minutissimum | 4 | 20 | 1 | 55 | 62 | 92 | 100 | 62 | 96 | 93 | 99 | 97 | 92 |
Corynebacterium coyleae | 2 | 4 | 4 | 28 | 29 | 93 | 100 | 48 | 91 | 43 | 100 | 100 | 93 |
Corynebacterium urealyticum | 4 | 2 | 4 | 4 | 4 | 92 | 100 | 2 | 92 | 100 | 100 | 56 | 100 |
Corynebacterium aurimucosum | 6 | 12 | 0 | 43 | 43 | 90 | 100 | 63 | 100 | 92 | 100 | 100 | 98 |