Lactic acidosis: Difference between revisions

Latest revision as of 17:11, 19 September 2024

Type A: clinical evidence of impaired tissue oxygenation
- Anaerobic muscle activity (increased oxygen demand)
  - Heavy exercise
  - Seizures
- Tissue hypoperfusion (decreased oxygen delivery)
  - Shock
  - Cardiac arrest
  - Regional ischemia (e.g. mesenteric ischemia)
- Tissue hypoia (decreased available oxygen or oxygen-carrying capacity)
  - Pulmonary hypoxia
  - Carbon monoxide
  - Severe anemia
Type B: No clinical evidence of impaired tissue oxygenation
- Type B1: Underlying disease
  - Renal failure
  - Liver failure (post-cellular)
  - Malignancy
  - HIV
  - Short gut syndrome (D-lactic acidosis)
- Type B2: drugs and toxins
  - Alcohols
  - Beta agonists
  - Biguanides
  - Carbon monoxide
  - Catecholamines
  - Cocaine
  - Cyanide/nitroprusside
  - Isoniazid
  - Linezolid
  - Nalidic acid
  - NRTIs
  - Propofol
  - Salicylates
  - Theophylline
  - Valproate
- Type B3: inborn errors of metabolism
  - Gluconeogenesis defects
  - Pyruvate dehydrogenase defects
  - Tricaroxylic acid cycle defects
  - Respiratory chain defects

Revision as of 01:17, 4 July 2020 (view source) Maintenance script (talk \| contribs) (Imported from text file)		Latest revision as of 17:11, 19 September 2024 (view source) Aidan (talk \| contribs) mNo edit summary
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