Amoxicillin-clavulanic acid: Difference between revisions

Latest revision as of 19:21, 23 June 2023

Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
Intravenous:
- Usual dose: 1 g (1000 mg/ 200 mg) IV every 8 hours
- High dose: 2 g (2000 mg/ 200 mg) IV every 8 to 12 hours

CrCl (mL/min)	Dose
Oral
>30	875/125 mg p.o. q12h
10-29	500/125 mg p.o. q12h
<10	500/125 mg p.o. q24h
Hemodialysis	500/125 mg p.o. q24h (given after dialysis on dialysis days)
Peritoneal dialysis	250/125 mg p.o. q12h
CRRT	Usual dose
Intravenous
>30	1 g IV q8h
10-29	1 g IV followed by 500 mg IV q12h
<10	1 g IV followed by 500 mg IV q24h
Hemodialysis	1 g IV followed by 500 mg IV q24h (given after dialysis on dialysis days)

@@ Line 1: / Line 1: @@
 ==Dosing==
 * Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
+* Intravenous:
-* Intravenous: 1 g (1.2 g) IV every 8 hours, or 2 g (2.2 g) IV every 8 to 12 hours
+** Usual dose: 1 g (1000 mg/ 200 mg) IV every 8 hours
+** High dose: 2 g (2000 mg/ 200 mg) IV every 8 to 12 hours
+=== Renal Dosing ===
+{| class="wikitable"
+!CrCl (mL/min)
+!Dose
+|-
+! colspan="2" |Oral
+|-
+|>30
+|875/125 mg p.o. q12h
+|-
+|10-29
+|500/125 mg p.o. q12h
+|-
+|<10
+|500/125 mg p.o. q24h
+|-
+|Hemodialysis
+|500/125 mg p.o. q24h (given after dialysis on dialysis days)
+|-
+|Peritoneal dialysis
+|250/125 mg p.o. q12h
+|-
+|CRRT
+|Usual dose
+|-
+! colspan="2" |Intravenous
+|-
+|>30
+|1 g IV q8h
+|-
+|10-29
+|1 g IV followed by 500 mg IV q12h
+|-
+|<10
+|1 g IV followed by 500 mg IV q24h
+|-
+|Hemodialysis
+|1 g IV followed by 500 mg IV q24h (given after dialysis on dialysis days)
+|}
 [[Category:β-lactams‏‎]]
 [[Category:Β-lactamase inhibitors]]