Hepatic tuberculosis: Difference between revisions
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* Infection of the liver by [[Mycobacterium tuberculosis]] |
* Infection of the liver by [[Mycobacterium tuberculosis]] |
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* Occurs in about 1% of all cases of TB, but likely more common in miliary disease and those with more severe pulmonary disease |
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* More common than hepatic [[tuberculoma]] |
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== Clinical Manifestations == |
== Clinical Manifestations == |
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* Most commonly presents with hepatomegaly and fever |
* Most commonly presents with hepatomegaly and fever |
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* Also respiratory symptoms, abdominal pain, and weight loss are common |
* Also respiratory symptoms, abdominal pain, and weight loss are common |
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* Elevated ALP and GGT |
* Elevated ALP and GGT common; only occasional ALT and AST elevation |
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== Diagnosis == |
== Diagnosis == |
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Latest revision as of 19:34, 13 June 2023
Background
- Infection of the liver by Mycobacterium tuberculosis
- Occurs in about 1% of all cases of TB, but likely more common in miliary disease and those with more severe pulmonary disease
- More common than hepatic tuberculoma
Clinical Manifestations
- Most commonly presents with hepatomegaly and fever
- Also respiratory symptoms, abdominal pain, and weight loss are common
- Elevated ALP and GGT common; only occasional ALT and AST elevation
Diagnosis
- Poor sensitivity of liver biopsy showing AFB and growing tuberculosis, but PCR often positive
- Histology usually shows caseating granuloma
Management
- As per other forms of Mycobacterium tuberculosis, duration of 6 to 12 months
Further Reading
- Hickey AJ, Gounder L, Moosa MY, Drain PK. A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection. BMC Infect Dis. 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103; PMCID: PMC4425874.
