Zika virus - Revision history

Aidan: /* Clinical Manifestations */

2020-09-20T13:50:48Z

Clinical Manifestations

← Older revision		Revision as of 13:50, 20 September 2020
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	*Incubation period of [[Usual incubation period::3 to 14 days]]		*Incubation period of [[Usual incubation period::3 to 14 days]]
	*[[Causes::Fever]], [[Causes::rash]], [[Causes::arthralgias]], [[Causes::conjunctivitis]], and [[Causes::headache]]		*[[Causes::Fever]], [[Causes::rash]], [[Causes::arthralgias]], [[Causes::conjunctivitis]], and [[Causes::headache]]
			*May also see [[Causes::thrombocytopenia]], and can be severe enough to cause abnormal bleeding or hematomas
	*Usually self-limited, lasting around 5 days		*Usually self-limited, lasting around 5 days

			=== Postinfectious Complications ===

	*Can have neurological disease in some cases, primarily presenting as [[Causes::Guillain-Barré syndrome]]		*Can have neurological disease in some cases, primarily presenting as [[Causes::Guillain-Barré syndrome]]
			*Rarely, [[acute myelitis]], [[meningoencephalitis]], [[acute disseminated encephalomyelitis]], [[reverse sensory polyneuropathy]]
⚫	*With maternal infection, causes a congenital syndrome of CNS abnormalities including [[~~Causes::~~microcephaly]], intracranial calcifications, lissencephaly, pachygyria, and vision and hearing loss

			=== Congenital Infection ===

		⚫	*With maternal infection, causes a [[Congenital Zika\|congenital syndrome]] of CNS abnormalities including [[microcephaly]], [[CNS calcifications in neonates\|intracranial calcifications]], [[lissencephaly]], [[pachygyria]], and vision and hearing loss

	==Differential Diagnosis==		==Differential Diagnosis==

Aidan: /* Differential Diagnosis */

2020-08-22T18:12:21Z

Differential Diagnosis

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-* Single-stranded, positive-sense RNA virus in the [[Flaviviridae]] family, genus [[Flavivirus]]
+*Single-stranded, positive-sense RNA virus in the [[Flaviviridae]] family, genus [[Flavivirus]]
-* Discovered in 1947 in Zika Forest, Uganda
+*Discovered in 1947 in Zika Forest, Uganda
-* Vector-borne infection carried primarily by [[Vector::Aedes aegypti]] mosquitoes, but possibly also [[Vector::Aedes albopictus]] mosquitoes
+*Vector-borne infection carried primarily by [[Vector::Aedes aegypti]] mosquitoes, but possibly also [[Vector::Aedes albopictus]] mosquitoes
-* Sexual transmission appears to be possible
+*Sexual transmission appears to be possible
-* Now essentially endemic in tropics worldwide
+*Now essentially endemic in tropics worldwide
 ==Clinical Manifestations==
@@ Line 16: / Line 16: @@
 *With maternal infection, causes a congenital syndrome of CNS abnormalities including [[Causes::microcephaly]], intracranial calcifications, lissencephaly, pachygyria, and vision and hearing loss
-== Differential Diagnosis ==
+==Differential Diagnosis==
-* [[Dengue]]
+*[[Dengue|Dengue virus]]
 ==Investigations==
@@ Line 25: / Line 87: @@
 *Serology can be tested after 10 days of symptoms, but is non-specific
-== Management ==
+==Management==
-* Supportive
+*Supportive
-* For risk of congenital disease
+*For risk of congenital disease
-** If asymptomatic, no need to delay attempts at conception
+**If asymptomatic, no need to delay attempts at conception
-** If symptomatic and diagnosis is confirmed, counsel to delay attempts at conception for 2 months (women) or 3 months (men) after return from the endemic area
+**If symptomatic and diagnosis is confirmed, counsel to delay attempts at conception for 2 months (women) or 3 months (men) after return from the endemic area
-** If symptomatic and diagnosis is not confirmed, then discuss with the patient
+**If symptomatic and diagnosis is not confirmed, then discuss with the patient
-** If the woman is pregnant and man has compatible symptoms, should abstain from unprotected sex for the duration of pregnancy
+**If the woman is pregnant and man has compatible symptoms, should abstain from unprotected sex for the duration of pregnancy
 [[Category:Flaviviridae]]

Aidan at 15:04, 19 August 2020

2020-08-19T15:04:13Z

← Older revision		Revision as of 15:04, 19 August 2020
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	== ~~Clinical Manifestations~~ ==		== Background ==

			* Single-stranded, positive-sense RNA virus in the [[Flaviviridae]] family, genus [[Flavivirus]]
	* History
			* Discovered in 1947 in Zika Forest, Uganda
	** Fevers
			* Vector-borne infection carried primarily by [[Vector::Aedes aegypti]] mosquitoes, but possibly also [[Vector::Aedes albopictus]] mosquitoes
	** Rash
			* Sexual transmission appears to be possible
	** Arthralgias
			* Now essentially endemic in tropics worldwide
	* Signs & Symptoms

			==Clinical Manifestations==
⚫	== Investigations ==

			*75% are asymptomatic
	* Labs
			*Incubation period of [[Usual incubation period::3 to 14 days]]
	** Serum rRT-PCR
			*[[Causes::Fever]], [[Causes::rash]], [[Causes::arthralgias]], [[Causes::conjunctivitis]], and [[Causes::headache]]
			*Usually self-limited, lasting around 5 days
			*Can have neurological disease in some cases, primarily presenting as [[Causes::Guillain-Barré syndrome]]
			*With maternal infection, causes a congenital syndrome of CNS abnormalities including [[Causes::microcephaly]], intracranial calcifications, lissencephaly, pachygyria, and vision and hearing loss

			== Differential Diagnosis ==

			* [[Dengue]]

		⚫	==Investigations==

			*Serum rRT-PCR, ideally done within 10 days of symptoms onset
			*Serology can be tested after 10 days of symptoms, but is non-specific

			== Management ==

			* Supportive
			* For risk of congenital disease
			** If asymptomatic, no need to delay attempts at conception
			** If symptomatic and diagnosis is confirmed, counsel to delay attempts at conception for 2 months (women) or 3 months (men) after return from the endemic area
			** If symptomatic and diagnosis is not confirmed, then discuss with the patient
			** If the woman is pregnant and man has compatible symptoms, should abstain from unprotected sex for the duration of pregnancy

	[[Category:Flaviviridae]]		[[Category:Flaviviridae]]

Aidan: Text replacement - "== Presentation" to "== Clinical Manifestations"

2020-08-02T12:17:55Z

Text replacement - "== Presentation" to "== Clinical Manifestations"

← Older revision		Revision as of 12:17, 2 August 2020
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	== ~~Presentation~~ ==		== Clinical Manifestations ==

	* History		* History

Aidan at 11:17, 16 August 2019

2019-08-16T11:17:14Z

← Older revision		Revision as of 11:17, 16 August 2019
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	= Presentation =		== Presentation ==

	* History		* History
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	* Signs & Symptoms		* Signs & Symptoms

	= Investigations =		== Investigations ==

	* Labs		* Labs

Aidan: /* Definition */

2019-08-13T19:58:13Z

Definition

← Older revision		Revision as of 19:58, 13 August 2019
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	= Definition =

	* Infection with the Zika virus

	= Presentation =		= Presentation =

Aidan at 11:35, 13 August 2019

2019-08-13T11:35:13Z

← Older revision		Revision as of 11:35, 13 August 2019
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	= ~~Zika~~ =		= Definition =

	== Definition ==

	* Infection with the Zika virus		* Infection with the Zika virus

	== Presentation ==		= Presentation =

	* History		* History
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	* Signs & Symptoms		* Signs & Symptoms

	== Investigations ==		= Investigations =

	* Labs		* Labs
	** Serum rRT-PCR		** Serum rRT-PCR

			[[Category:Flaviviridae]]

Aidan: Aidan moved page RNA Zika virus to Zika virus without leaving a redirect

2019-08-13T11:34:20Z

Aidan moved page RNA Zika virus to Zika virus without leaving a redirect

← Older revision	Revision as of 11:34, 13 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:57Z

Imported from text file

New page

= Zika =

== Definition ==

* Infection with the Zika virus

== Presentation ==

* History
** Fevers
** Rash
** Arthralgias
* Signs & Symptoms

== Investigations ==

* Labs
** Serum rRT-PCR